Analysis of the chloramphenicol resistance determinant of plasmid R26
Citation:
Charles James Dorman, 'Analysis of the chloramphenicol resistance determinant of plasmid R26', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 1985, pp 296Download Item:
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Abstract:
The Inc P-1 plasmid, R2B carries an inducible chloramphenicol resistance determinant, cml. This specifies low level chloramphenicol resistance (30 μg/ml] in Escherichia coli. The mechanism does not involve drug detoxification or ribosomal modification, but may involve a permeability barrier to drug uptake acting at the cytoplasmic membrane. Experiments described in this thesis show that cml also specifies resistance to some fluorinated derivatives of chloramphenicol.
Author: Dorman, Charles James
Advisor:
Foster, TimothyQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
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thesisAvailability:
Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinLicences: