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Recent Submissions

  • Discovery and engineering of antimicrobial peptides to combat food spoilage 

    BECKETT, MICHAEL CHRISTOPHER (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)
    This work sought to use a bioinformatics based approach to discover plant derived antimicrobial peptides which were structurally similar to human β-defensin 3 (HBD3) and which possessed effective antimicrobial activity ...
  • FNR is a regulator of Salmonella pathogenicity Island 2 in Salmonella Typhimurium 

    KARY, STEFANI CHRISTINE (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)
    During infection, S. Typhimurium employs Salmonella pathogenicity island (SPI)-encoded type three secretion systems (T3SS) 1 and 2 to invade and survive in host cells. However, expression of SPI-2 is seen at the epithelial ...
  • DNA supercoiling and transcription: a two-way street 

    Dorman, Charles (2019)
    Background : The processes of DNA supercoiling and transcription are interdependent because the movement of a transcription elongation complex simultaneously induces under- and over winding of the DNA duplex and because ...
  • Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin 

    TOWELL, AISLING (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)
    The skin of atopic dermatitis (AD) patients is frequently colonised by Staphylococcus aureus. Colonisation by S. aureus correlates with disease severity and exacerbated disease symptoms. The factors involved in S. aureus ...
  • A novel anti-viral role for STAT3 in IFN-α signalling responses. 

    Stevenson, Nigel; Bowie, Andrew; Roberts, Kim; Bourke, Nollaig; O'Farrelly, Cliona (Springer, 2017-05)
    The cytokine, Interferon (IFN)-α, induces a wide spectrum of anti-viral mediators, via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1 and STAT2 are well characterised ...

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