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Microbiology (Theses and Dissertations)
Recent Submissions
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Investigating chromatin remodelling by the Swi-Snf and Tup1-Cyc8 complexes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)Swi-Snf is an ATP-dependent chromatin remodelling complex which generally acts as a co-activator of gene transcription via its removal of promoter nucleosomes. Conversely, Tup1-Cyc8 (Ssn6) is a co-repressor complex which ... -
Unravelling a food derived bioactive peptide with dual functionality of antimicrobial and immunomodulatory properties
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)In this thesis, a computational data mining and feature based approach to unravel the abundance of unexplored peptides from nature and to identify potent, novel antimicrobial peptides (AMPs) from phyto-proteins is proposed. ... -
Broad scale redistribution of mRNA abundance and transcriptional machinery in response to growth rate in Salmonella enterica serovar Typhimurium
(2017)We have investigated the connection between the four-dimensional architecture of the bacterial nucleoid and the organism's global gene expression programme. By localizing the transcription machinery and the transcriptional ... -
Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium
(2017)Indirect readout mechanisms of transcription control rely on the recognition of DNA shape by transcription factors (TFs). TFs may also employ a direct readout mechanism that involves the reading of the base sequence in the ... -
When is a transcription factor a NAP?
(2020)Proteins that regulate transcription often also play an architectural role in the genome. Thus, it has been difficult to define with precision the distinctions between transcription factors and nucleoid-associated proteins ...
