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Microbiology (Scholarly Publications)
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Microbiology (Theses and Dissertations)
Recent Submissions
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IL-33 and IL-18 in inflammatory bowel disease etiology and microbial interactions
(2019)The IL-1 cytokines are a newly expanded family, with each of its 11 members playing an important role in health and disease. Typically acting as pro- or anti-inflammatory mediators of first-line innate immunity, their ... -
Establishing Boundaries: The Relationship That Exists between Intestinal Epithelial Cells and Gut-Dwelling Bacteria.
(2019)The human gastrointestinal (GI) tract is a highly complex organ in which various dynamic physiological processes are tightly coordinated while interacting with a complex community of microorganisms. Within the GI tract, ... -
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
(2018)Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced ... -
Significance of the chromosomal positions of the genes encoding Integration Host Factor and DNA gyrase in Salmonella.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)In this thesis, two studies are described that built upon the idea of the chromosomal gene importance. In both studies Salmonella was used as a model organism. In the first study, ihfA and ihfB ? genes that encode ... -
Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis
(2018)Background and aims: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated the role of microRNA-21 [miR-21] in the pathogenesis of intestinal inflammation, ...
