Browsing by Subject "Microbiology, Ph.D."
Now showing items 1-20 of 76
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A role for proteases and transcriptional regulation in the expression of ClfB on the surface of staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Staphylococcus aureus is an important human pathogen. This bacterium expresses proteins on its surface capable of binding to many host ligands including fibrinogen, fibronectin, collagen, elastin and von Willebrand factor. ... -
Adhesion and invasion by Escherichia coli K1
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Escherichia coli is one of the principal causes of septicaemia and meningitis in neonates. Sepsis occurs in approximately one in every thousand live births, with up to 10% progressing to develop meningitis. A disproportionate ... -
Analysis and development of the recombinant Semliki Forest virus vector as a cancer gene therapy agent
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Increased understanding of the molecular pathogenesis of cancer has shown that its accumulation is the result of multiple genetic alterations. Cancer is a disease of altered genes, with the most predominantly altered ... -
Analysis of the chloramphenicol resistance determinant of plasmid R26
(Trinity College (Dublin, Ireland). Department of Microbiology, 1985)The Inc P-1 plasmid, R2B carries an inducible chloramphenicol resistance determinant, cml. This specifies low level chloramphenicol resistance (30 μg/ml] in Escherichia coli. The mechanism does not involve drug detoxification ... -
Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Long-term potentiation (LTP) is considered to be a possible neurophysiological model for learning and memory and consistent with this, is the observation that LTP is sensitive to stress, injury and insult. This thesis ... -
Analysis of the function of the N1 subdomain of MSCRAMMs of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014)The Microbial Surface Component Recognising Adhesive Matrix Molecules (MSCRAMMs) family of cell wall-associated proteins have recently been reclassified based on structure-function analysis. Under this new regime the MSCRAMM ... -
Analysis of the genomic organisation and gene expression of brewery strains of yeast
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)The genomes of lager yeast arose from the fusion of two yeast strains most closely resembling Saccharomyces cerevisiae and Saccharomyces bayanus. The resultant strains have subsequently undergone genome duplications ... -
Analysis of the role of human papillomaviruses and the p53/Rb tumour suppressor genes in the development of cutaneous squamous cell carcinoma
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)Nonmelanoma skin cancers (NMSC) are the most frequent cancers in Caucasian populations. Renal transplant recipients (RTR) are at an increased risk of neoplasia, particularly skin cancer. Studies on anogenital cancer have ... -
Antimicrobial peptide preventing beer spoilage
(Trinity College (Dublin, Ireland). Department of Microbiology, 2012)Beer spoilage micro-organisms (BSMs) are a common threat to Master Brewers worldwide. Numerous studies have been carried out to date to overcome this problem, yet the most common preventative measure is the addition of ... -
Biasing switching outcomes in the Escherichia coli fim site-specific recombination system through DNA supercoiling and nucleoid-associated proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Type 1 fimbriae are typically expressed in nutrient poor environments and facilitate colonization through attachment when the bacterium can no longer support a motile lifestyle that demands a high metabolic flux. They play ... -
Biogenesis of histone mRNAs in the yeast Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The typical eukaryotic human diploid cell contains 3.2x10 9 base pairs of deoxyribonucleic acid (DNA) which, if presented in an extended form, would measure 1.2m in length. The large amount of DNA is tightly wrapped and ... -
Biomass to biofuel : the engineering of Saccharomyces species for the co-fermentation of cellulose and xylose
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Lignocellulose represents one of the most abundant biomass sources in the world. Its renewable and abundant nature makes it a prime target for use in bioethanol production. The efficient conversion of lignocellulosic biomass ... -
Biomass to biofuel : towards the bioengineering of Saccharomyces species for cellulose degradation
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Cellulose is the most abundant polysaccharide on earth and therefore represents a major reservoir of sugar that could be potentially converted to alcohol and used as a fuel source. The filamentous fungus Trichoderma reesei ... -
Characterisation of genotypic and phenotypic differences between Candida dubliniensis and Candida albicans
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Summary -Candida dubliniensis is a recently described Candida species associated with oral candidosis in Human Immunodeficiency Virus (HIV)-infected and AIDS patients. The phylogenetic position of C. dubliniensis has ... -
Characterisation of SdrC, SdrD and SdrE from the serine-aspartate repeat family of Staphylococcus auerus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Staphylococcus aureus is an important human pathogen. The ability of S. aureus to initiate infection is attributed at least partly to the expression of cell wall-associated proteins known as MSCRAMMs (microbial surface ... -
Characterisation of Sfh, a novel H-NS-like protein
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Members of the H-NS protein family are widespread among Gram-negative bacteria and are known to influence gene expression at a global level. Shigella flexneri serotype 2a strain 2457T expresses three members of the H-NS ... -
Characterisation of the Elastin Binding Protein (EbpS) of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Staphylococcus aureus expresses an array of surface proteins that promote interaction of the bacterium with the host. Some surface proteins promote binding to components of the host extracellular matrix and can act as ... -
Characterisation of the Rns transcriptional regulator of enterotoxigenic Escherichia coli and regulationf of CS1 fimbrial expression
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea amongst children in developing countries and travellers to such countries. Virulence in ETEC is dependent on both toxin production and adherence of the ... -
Characterization of peptide mimics to antigens chaperoned by Hsp70 in MDA-MB-231 breast tumour cells
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Tumour-derived heat shock protein (Hsp) preparations have been shown to elicit anti-tumour immune responses in both mice and man. Analysis of Hsp preparations from tumour cells revealed that the immuno-protective property ... -
Construction and characterisation of a Semliki Forest virus vector based rubella prototype vaccine
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Alphavirus vaccines such as those based on the Semliki Forest virus (SFV) replicon have been widely studied as candidate vaccines. Following intramuscular injection, dispersal of the RNA occurs to the local lymph node only, ...