Browsing School of Biochemistry & Immunology by Title
Now showing items 540-559 of 1015
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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
(Springer Nature, 2023-03-08)Metabolic rewiring underlies the effector functions of macrophages, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory ... -
Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss
(2022)Macrophages are abundant in the cochlea; however, their role in hearing loss is not well understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an inflammatory response, which includes ... -
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
(2012)Chronic activation of mammalian target of rapamycin complex 1 (mTORC1) and p70 S6 kinase (S6K) in response to hypernutrition contributes to obesity-associated metabolic pathologies, including hepatosteatosis and insulin ... -
Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4
(The American Society for Biochemistry and Molecular Biology, 2004)The Toll-interleukin-1 receptor domain-containing adapter Mal (MyD88 adapter-like protein) is involved in Toll-like receptor (TLR)-2 and TLR4 signal transduction. However, no studies have yet identified a function for Mal ... -
Mal is not esential for TLR2 signalling and inhibits signalling by TLR3
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)This thesis set out to systematically analyse the role of Mai in signalling by TLR2, TLR3 and TLR4 in murine macrophages and dendritic cells. It has revealed that Mai is not essential to TLR2 signal transduction, is required ... -
Mal, more than a bridge to MyD88
(2013) -
Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
(2017)STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite ( Plasmodium falciparum ) or other pathogen DNA. As P. falciparum infects red blood cells and not leukocytes, how parasite DNA ... -
Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
(2021)Pathogens are thought to use host molecular cues to control when to initiate life-cycle transitions, but these signals are mostly unknown, particularly for the parasitic disease malaria caused by Plasmodium falciparum. ... -
Malonylation of GAPDH in the inflammatory response in macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Succinylation and malonylation are two recently discovered protein post-translational modifications. They involve the attachment to lysines of metabolism-derived succinyl and malonyl groups respectively, resulting in a ... -
Malonylation of GAPDH is an inflammatory signal in macrophages
(2019)Macrophages undergo metabolic changes during activation that are coupled to functional responses. The gram negative bacterial product lipopolysaccharide (LPS) is especially potent at driving metabolic reprogramming, enhancing ... -
Manipulating regulatory responses in antitumour immunity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)The immune system has evolved tolerogenic and regulatory mechanism to control responses to self-antigens and to ensure that the inflammatory immune response to pathogens does not cause excessive tissue damage during ... -
Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection.
(2015)The capacity for intracellular survival within phagocytes is likely a critical factor facilitating the dissemination of Staphylococcus aureus in the host. To date, the majority of work on S. aureus-phagocyte interactions ... -
Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1.
(2012)Eukaryotic cells have developed a diverse repertoire of Rab GTPases to regulate vesicle trafficking pathways. Together with their effector proteins, Rabs mediate various aspects of vesicle formation, tethering, docking ... -
Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components
(The American Society for Biochemistry and Molecular Biology, 2007)We investigated the composition of the endogenous ligand-bound type I interleukin-1 (IL-1) receptor (IL-1RI) signaling complex using immunoprecipitation and tandem mass spectrometry. Three proteins with approximate molecular ... -
Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification
(American Academy of Pediatrics, 2009)OBJECTIVE. Folic acid fortification has reduced neural tube defect prevalence by 50% to 70%. It is unlikely that fortification levels will be increased to reduce neural tube defect prevalence further. Therefore, it is ... -
A mechanism for bistability in glycosylation
(2018)Glycosyltransferases are a class of enzymes that catalyse the posttranslational modification of proteins to produce a large number of glycoconjugate acceptors from a limited number of nucleotide-sugar donors. The products ... -
Mechanisms of gasdermin pore formation in response to viral sensing in human respiratory epithelial cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)A key component of the innate immune response to infection or cellular stress is the activation of inflammasomes which leads to gasdermin (GSDM) pore formation, interleukin-1β (IL-1β) release and lytic cell death. GSDMs ... -
Mechanisms of immunomodulatory activity of Cholera toxin
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)Cholera toxin (CT), a major enterotoxin produced by Vibrio cholerae, is a potent mucosal adjuvant that promotes type 2 T helper cell (Th2) responses to coadministered foreign antigen. However, the mechanisms involved in ... -
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation: Contributions of Src- and receptor-tyrosine kinases
(American Society for Biochemistry and Molecular Biology, 2005)The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine signal transduction. SOCS3 is a key negative regulator of interleuking-6 (IL-6) signal transduction. Furthermore, SOCS3 was shown ... -
Mechanistic and functional studies on biliverdin IXa reductase from the cyanobacterium synechocystis sp.PCC6803
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The enzymes of heme metabolism and phycobilin biosynthesis in the cyanobacterium Synechocystis sp. PCC6803, along with their reducing partners, ferredoxin and ferredoxin reductase were produced through recombinant DNA ...