Browsing School of Biochemistry & Immunology by Title
Now showing items 998-1015 of 1015
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Vaccine trials during a pandemic: potential approaches to ethical dilemmas
(2021)Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge. ... -
Vaccine-induced protective immunity to Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Whooping cough (pertussis) is an infectious disease caused by the respiratory pathogen Bordetella pertussis that is re-emerging in many developed countries, despite extensive vaccine coverage. One of the proposed reasons ... -
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
(2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ... -
Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
(2011)Recognition of viruses by pattern recognition receptors (PRRs) causes interferon-? (IFN-?) induction, a key event in the anti-viral innate immune response, and also a target of viral immune evasion. Here the vaccinia virus ... -
Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection
(2010)CD209, a c-type lectin expressed by dendritic cells (DCs), acts as a pathogen recognition receptor. A single nucleotidepolymorphism (SNP) in the promoter region of CD209(-336A/G;rs4804803) affects transcription and is ... -
A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection
(2010)CD209, a c-type lectin expressed by dendritic cells (DCs) acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is ... -
Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection
(2013)Pegylated-IFN and ribavirin remains the current treatment for chronic HCV infection in patients co-infected with HIV-1, but this regimen has low efficacy rates, particularly for HCV genotype 1/4 infection, has severe side ... -
Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule
(2010)TLRs are critical pattern recognition receptors, which recognize bacterial and viral pathogen associated molecular patterns leading to innate and adaptive immune responses. TLRs signal via homotypic interactions between ... -
Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase
(2000)The transcription factor NF-kappaB is a central mediator of altered gene expression during inflammation, and is implicated in a number of pathologies, including cancer, atherosclerosis, and viral infection. We report in ... -
The Warburg effect then and now: From cancer to inflammatory diseases
(2013)Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon ... -
Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium.
(2015)Background Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired ... -
Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?
(2019)Staphylococcus aureus bloodstream infection can have potentially catastrophic consequences for patients on hemodialysis. Consequently, an effective vaccine to prevent S aureus infection would have a significant influence ... -
X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex
(2016)Serial femtosecond X-ray crystallography (SFX) using an X-ray free electron laser (XFEL) is a recent advancement in structural biology for solving crystal structures of challenging membrane proteins, including G-protein ... -
α-Lactalbumin-oleic acid complex : structure function dynamics
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Human alpha-lactalbumin made lethal to tumor cells (HAMLET) and its analogues are partially unfolded protein-oleic acid complexes that exhibit selective tumoricidal activity normally absent in the native protein itself, ... -
β-Defensins: Farming the microbiome for homeostasis and health
(2019)Diverse commensal populations are now regarded as key to physiological homeostasis and protection against disease. Although bacteria are the most abundant component of microbiomes, and the most intensively studied, the ... -
γδ T cells and NK cells – Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity.
(2015)Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease that affects the central nervous system (CNS) resulting in progressive cognitive decline and physical disability. Experimental autoimmune encephalomyelitis ...
