Browsing School of Biochemistry & Immunology by Title
Now showing items 313-332 of 1015
-
Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation
(2014)Protein N-glycosylation is a common post-translational modification that produces a complex array of branched glycan structures. The levels of branching, or antennarity, give rise to differential biological activities for ... -
Gating topology of the proton-coupled oligopeptide symporters
(2015)Peptide transport is the main route through which the body absorbs and retains dietary protein and hence plays an important role in human physiology (Steinhardt and Adibi, 1986). The combined action of acid hydrolysis in ... -
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
(American Society of Hematology, 2003)A modestly elevated total plasma homocysteine concentration (tHcy) is generally accepted as an independent and graded risk factor for various pathologies, including vascular diseases, neural tube defects, Alzheimer disease, ... -
Genetic variation in bulls divergent for fertility
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Bovine fertility remains a critical issue underpinning the sustainability of the agricultural sector. Since the realisation of an unfavourable relationship between fertility and production traits in cattle, methods to ... -
Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene
(2013)The enteropathogen Campylobacter jejuni is a major worldwide health and economic burden, being one of the leading causes of bacterial gastroenteritis and commonly linked to postinfectious onset of autoimmune disease. ... -
Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes
(2011)Background: Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact. Recent studies have highlighted the role of functional genomics to better ... -
Genotype variation at the MSTN locus is associated with skeletal muscle Coenzyme Q level in untrained Thoroughbred horses.
(2019)In the finely-tuned athletic species of Thoroughbred horses, polymorphisms (Intro 1 SNP g.66493737C>T and SINE insertion 227bp in promoter) in the myostatin gene (MSTN), a pronounced inhibitor of skeletal muscle growth, ... -
GlcNAc transferases and glycoengineering in Chinese hamster ovary cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Glycosylation constitutes one of the most important post-translational modifications of proteins, with over 60% of proteins known to be glycosylated. GlcNAc transferases (GnTs) belong to a large subfamily of glycosyltransferases ... -
Gliadin antibody detection in gluten enteropathy.
(1986)Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be ... -
Global gene expression analysis of chicken caecal response to Campylobacter jejuni
(Elsevier, 2011)Campylobacter jejuni colonises the caecum of more than 90% of commercial chickens. Even though colonisation is asymptomatic, we hypothesised that it is mediated by activation of several biological pathways. We therefore ... -
Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like
(2008)Phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) is essential for the induction of promoters which contain the interferon-stimulated response element (ISRE). IRF3 can be activated by Toll-like ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)NLRP3 inflammasome activation contributes to chronic inflammationassociated with autoinflammatorydisease, yet understanding of NLRP3inflammasome regulation is incomplete.Hughes et al. show that thedeglutathionylating enzyme ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and ... -
Glycerol-3-phosphatase from Trypanosoma brucei brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Glycerol-3-phosphatase activity was found in both bloodstream and procyclic form o f trypanosomes with a specific activity of 35 nmol/min/mg of protein and 28 nmol/min/mg of protein respectively. The localisation of the ... -
GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources.
(2010)Background: The display of N-glycan carbohydrate structures is an essential part of glycoinformatics. Several tools exist for building such structures graphically, by selecting from a palette of symbols or sugar names, ... -
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element
(2004)Background: Hepatic expression of several gene products involved in glucose metabolism, including phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase) and insulin-like growth factor binding protein-1 ... -
The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation.
(PLoS, 2009)Bloodstream forms of Trypanosoma brucei contain a glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC) that cleaves the GPI-anchor of the variable surface glycoprotein (VSG). Its location in trypanosomes has ... -
The GOLD Domain-containing Protein TMED1 Is Involved in Interleukin-33 Signaling.
(2013)The proinflammatory danger signal IL-33, which is released from damaged or dying cells, achieves its effects via the IL-1R family member ST2L. The detection of IL-33 by ST2L initiates downstream signaling pathways that ... -
Gone or Misplaced?: Investigation of Memory Engrams Across Development
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)All humans experience amnesia. While about 30% of adults who live to be over 65 will suffer from dementia, 100% of the human population experiences infantile amnesia, which is the loss of memories formed in early childhood ...