Manipulating regulatory responses in antitumour immunity
Citation:
Karen Galvin, 'Manipulating regulatory responses in antitumour immunity', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011, pp 291Download Item:
Abstract:
The immune system has evolved tolerogenic and regulatory mechanism to control responses to self-antigens and to ensure that the inflammatory immune response to pathogens does not cause excessive tissue damage during infection. Whilst regulatory T cells (Treg) play a pivotal role in maintaining immune tolerance, tumour cells have the capacity to exploit the regulatory mechanisms of the immune system to evade anti-tumour effector immune responses. Immune subversion by tumours, especially their ability to induce or activate Treg cells, is a major barrier in the development of effective immunotherapeutics and vaccines against cancer. Therefore, in order to develop a successful therapeutic vaccine against cancer, immune tolerance must be overcome to allow the generation of anti-tumour CD4+ Th1 cells and CD8+ cytotoxic T lymphocyte (CTL) responses.
Author: Galvin, Karen
Advisor:
Mills, KingstonQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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