Biofabrication of vasculature in microphysiological models of bone.
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2021Access:
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David Hoey, Daniel Kelly, 'Biofabrication of vasculature in microphysiological models of bone.', 2021, Biofabrication;, 13;, 3;Download Item:
Abstract:
Bone contains a dense network of blood vessels that are essential to its homoeostasis, endocrine
function, mineral metabolism and regenerative functions. In addition, bone vasculature is
implicated in a number of prominent skeletal diseases, and bone has high affinity for metastatic
cancers. Despite vasculature being an integral part of bone physiology and pathophysiology, it is
often ignored or oversimplified in in vitro bone models. However, 3D physiologically relevant
vasculature can now be engineered in vitro, with microphysiological systems (MPS) increasingly
being used as platforms for engineering this physiologically relevant vasculature. In recent years,
vascularised models of bone in MPSs systems have been reported in the literature, representing the
beginning of a possible technological step change in how bone is modelled in vitro. Vascularised
bone MPSs is a subfield of bone research in its nascency, however given the impact of MPSs has
had in in vitro organ modelling, and the crucial role of vasculature to bone physiology, these
systems stand to have a substantial impact on bone research. However, engineering vasculature
within the specific design restraints of the bone niche is significantly challenging given the different
requirements for engineering bone and vasculature. With this in mind, this paper aims to serve as
technical guidance for the biofabrication of vascularised bone tissue within MPS devices. We first
discuss the key engineering and biological considerations for engineering more physiologically
relevant vasculature in vitro within the specific design constraints of the bone niche. We next
explore emerging applications of vascularised bone MPSs, and conclude with a discussion on the
current status of vascularised bone MPS biofabrication and suggest directions for development of
next generation vascularised bone MPSs.
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http://people.tcd.ie/kellyd9http://people.tcd.ie/dahoey
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Author: Hoey, David; Kelly, Daniel
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Journal ArticleSeries/Report no:
Biofabrication;13;
3;
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Full text availableDOI:
http://dx.doi.org/10.1088/1758-5090/ac04f7ISSN:
1758-5082Metadata
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