dc.contributor.author | Romero-Ortuno, Roman | |
dc.date.accessioned | 2021-08-17T09:49:06Z | |
dc.date.available | 2021-08-17T09:49:06Z | |
dc.date.issued | 2021 | |
dc.date.submitted | 2021 | en |
dc.identifier.citation | Teodoro J. Oscanoa, Xavier Vidal, Eliecer Coto, Roman Romero-Ortuno, ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis, Arterial Hypertension, 2021 | en |
dc.identifier.other | Y | |
dc.identifier.uri | https://journals.viamedica.pl/arterial_hypertension/article/view/AH.a2021.0018 | |
dc.identifier.uri | http://hdl.handle.net/2262/96818 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Background Hypertension and type 2 diabetes increase the risk of severe SARS-CoV-2 infection. On the other hand, homozygous ACE deletion polymorphism (DD) has been associated with these two diseases and risk of acute respiratory distress syndrome. Aim To conduct a metanalysis of the association between ACE gene I/D polymorphism (DD, II and DI) and severity of SARS-CoV-2 infection in hospitalized patients. Methods We searched PubMed, EMBASE and Google Scholar for studies published between January 2020 and April 2021. We included case-control studies evaluating the association between ACE I/D and severity of SARS-CoV-2 infection in hospitalized patients, were there was sufficient genotype or allele frequency data to calculate IRR (incidence rate ratio) and 95% confidence intervals (CIs). Results 5 studies were included (mean age 58.5 years and 61% men), combining to a total of 786 patients. Three studies were conducted in Caucasians. Overall, patients who had homozygous co-dominance genotype DD were at 47% higher risk of severe COVID-19 compared with II or ID (IRR: 1.47; 95% CI: 1.15-1.89; p=0.002). Conclusions The ACE DD genotype may confer a greater risk of severe COVID-19 in hospitalized patients. Further studies including more diverse ethnic groups are necessary to fully establish this association. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Arterial Hypertension; | |
dc.rights | Y | en |
dc.subject | ACE gene | en |
dc.subject | I/D polymorphism | en |
dc.subject | SARS-CoV-2 | en |
dc.subject | COVID-19 | en |
dc.subject | Meta-analysis | en |
dc.title | ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/romeroor | |
dc.identifier.rssinternalid | 232644 | |
dc.identifier.doi | 10.5603/AH.a2021.0018 | |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Ageing | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.orcid_id | 0000-0002-3882-7447 | |
dc.subject.darat_impairment | Age-related disability | en |
dc.subject.darat_thematic | Health | en |
dc.subject.darat_thematic | Third age/ageing | en |
dc.status.accessible | N | en |