ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis
File Type:
PDFItem Type:
Journal ArticleDate:
2021Author:
Access:
openAccessCitation:
Teodoro J. Oscanoa, Xavier Vidal, Eliecer Coto, Roman Romero-Ortuno, ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis, Arterial Hypertension, 2021Download Item:
146. AH ACE ID COVID-19.pdf (PDF) 830.3Kb
Abstract:
Background Hypertension and type 2 diabetes increase the risk of severe SARS-CoV-2 infection. On the other hand, homozygous ACE deletion polymorphism (DD) has been associated with these two diseases and risk of acute respiratory distress syndrome. Aim To conduct a metanalysis of the association between ACE gene I/D polymorphism (DD, II and DI) and severity of SARS-CoV-2 infection in hospitalized patients. Methods We searched PubMed, EMBASE and Google Scholar for studies published between January 2020 and April 2021. We included case-control studies evaluating the association between ACE I/D and severity of SARS-CoV-2 infection in hospitalized patients, were there was sufficient genotype or allele frequency data to calculate IRR (incidence rate ratio) and 95% confidence intervals (CIs). Results 5 studies were included (mean age 58.5 years and 61% men), combining to a total of 786 patients. Three studies were conducted in Caucasians. Overall, patients who had homozygous co-dominance genotype DD were at 47% higher risk of severe COVID-19 compared with II or ID (IRR: 1.47; 95% CI: 1.15-1.89; p=0.002). Conclusions The ACE DD genotype may confer a greater risk of severe COVID-19 in hospitalized patients. Further studies including more diverse ethnic groups are necessary to fully establish this association.
URI:
https://journals.viamedica.pl/arterial_hypertension/article/view/AH.a2021.0018http://hdl.handle.net/2262/96818
Author's Homepage:
http://people.tcd.ie/romeroorDescription:
PUBLISHED
Author: Romero-Ortuno, Roman
Type of material:
Journal ArticleURI:
https://journals.viamedica.pl/arterial_hypertension/article/view/AH.a2021.0018http://hdl.handle.net/2262/96818
Collections:
Series/Report no:
Arterial Hypertension;Availability:
Full text availableKeywords:
ACE gene, I/D polymorphism, SARS-CoV-2, COVID-19, Meta-analysisSubject (TCD):
Ageing , Immunology, Inflammation & InfectionDOI:
10.5603/AH.a2021.0018Licences: