dc.contributor.author | Dorman, Charles | en |
dc.date.accessioned | 2020-03-02T15:38:32Z | |
dc.date.available | 2020-03-02T15:38:32Z | |
dc.date.issued | 2020 | en |
dc.date.submitted | 2020 | en |
dc.identifier.citation | Dorman CJ, Schumacher MA, Bush MJ, Brennan RG, Buttner MJ, When is a transcription factor a NAP?, Current Opinion in Microbiology, 55, 2020, 26 - 33 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1369527420300242?via%3Dihub | |
dc.identifier.uri | http://hdl.handle.net/2262/91666 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Proteins that regulate transcription often also play an architectural role in the genome. Thus, it has been difficult to define with precision the distinctions between transcription factors and nucleoid-associated proteins (NAPs). Anachronistic descriptions of NAPs as 'histone-like' implied an organizational function in a bacterial chromatin-like complex. Definitions based on protein abundance, regulatory mechanisms, target gene number, or the features of their DNA-binding sites are insufficient as marks of distinction, and trying to distinguish transcription factors and NAPs based on their ranking within regulatory hierarchies or positions in gene-control networks is also unsatisfactory. The terms 'transcription factor' and 'NAP' are ad hoc operational definitions with each protein lying along a spectrum of structural and functional features extending from highly specific actors with few gene targets to those with a pervasive influence on the transcriptome. The Streptomyces BldC protein is used to illustrate these issues. | en |
dc.format.extent | 26 | en |
dc.format.extent | 33 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Current Opinion in Microbiology | en |
dc.relation.ispartofseries | 55 | en |
dc.rights | Y | en |
dc.subject | Nucleoid associated proteins | en |
dc.subject | DNA binding | en |
dc.title | When is a transcription factor a NAP? | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/cjdorman | en |
dc.identifier.rssinternalid | 208231 | en |
dc.identifier.doi | http://dx.doi.org/10.1016/j.mib.2020.01.019 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Genes & Society | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.rssuri | http://hdl.handle.net/2262/91666 | en |
dc.identifier.orcid_id | 0000-0002-6018-9170 | en |