When is a transcription factor a NAP?
Citation:
Dorman CJ, Schumacher MA, Bush MJ, Brennan RG, Buttner MJ, When is a transcription factor a NAP?, Current Opinion in Microbiology, 55, 2020, 26 - 33Download Item:
Dorman et al. 2020 COiM 55 26-33.pdf (PDF) 1.998Mb
Abstract:
Proteins that regulate transcription often also play an architectural role in the genome. Thus, it has been difficult to define with precision the distinctions between transcription factors and nucleoid-associated proteins (NAPs). Anachronistic descriptions of NAPs as 'histone-like' implied an organizational function in a bacterial chromatin-like complex. Definitions based on protein abundance, regulatory mechanisms, target gene number, or the features of their DNA-binding sites are insufficient as marks of distinction, and trying to distinguish transcription factors and NAPs based on their ranking within regulatory hierarchies or positions in gene-control networks is also unsatisfactory. The terms 'transcription factor' and 'NAP' are ad hoc operational definitions with each protein lying along a spectrum of structural and functional features extending from highly specific actors with few gene targets to those with a pervasive influence on the transcriptome. The Streptomyces BldC protein is used to illustrate these issues.
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https://www.sciencedirect.com/science/article/pii/S1369527420300242?via%3Dihubhttp://hdl.handle.net/2262/91666
Author's Homepage:
http://people.tcd.ie/cjdormanDescription:
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Author: Dorman, Charles
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Journal ArticleURI:
https://www.sciencedirect.com/science/article/pii/S1369527420300242?via%3Dihubhttp://hdl.handle.net/2262/91666
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Series/Report no:
Current Opinion in Microbiology55
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Full text availableKeywords:
Nucleoid associated proteins, DNA bindingSubject (TCD):
Genes & Society , Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1016/j.mib.2020.01.019Licences: