dc.contributor.author | Senge, Mathias | |
dc.contributor.author | Callaghan, Susan | |
dc.contributor.author | Filatov, Mikhail A. | |
dc.contributor.author | Savoie, Huguette | |
dc.contributor.author | Boyle, Ross W. | |
dc.date.accessioned | 2020-02-05T11:51:15Z | |
dc.date.available | 2020-02-05T11:51:15Z | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019 | en |
dc.identifier.citation | Callaghan, S., Filatov, M.A., Savoie, H., Boyle, R.W. & Senge, M.O., A lead BODIPY-phenylanthracene dyad for application in photodynamic therapy, 2019, Proceedings of SPIE - The International Society for Optical Engineering, 11070, 110709I | en |
dc.identifier.other | Y | |
dc.identifier.uri | https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11070/2525246/A-lead-BODIPY-phenylanthracene-dyad-for-application-in-photodynamic-therapy/10.1117/12.2525246.short?SSO=1 | |
dc.identifier.uri | http://hdl.handle.net/2262/91453 | |
dc.description.abstract | Over the past four years we have developed BODIPY dyads capable of triplet state generation from a charge transfer
states generated by photoinduced electron transfer. In the current work we identify a lead compound for application in
photodynamic therapy. This system is composed of a phenylanthracene electron donor unit and a dimethyl-substituted
BODIPY acceptor unit. We have demonstrated that this compound, in submicromolar concentrations, can effectively
generate singlet oxygen in polar solvents and induce cytotoxicity in human breast cancer cells (MDA-MB-468) when
exposed to light. The photophysical properties of these compounds are chemically tunable and thus open the door not
only to a new class of photodynamic therapy photosensitizers but also agents for triplet-triplet annihilation up-conversion
applications | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Proceedings of SPIE - The International Society for Optical Engineering; | |
dc.relation.ispartofseries | 11070; | |
dc.relation.ispartofseries | 110709I; | |
dc.rights | Y | en |
dc.subject | BODIPY | en |
dc.subject | Photodynamic therapy | en |
dc.subject | Triplet state | en |
dc.subject | Singlet oxygen | en |
dc.subject | Photosensitizer | en |
dc.title | A lead BODIPY-phenylanthracene dyad for application in photodynamic therapy | en |
dc.type | Conference Paper | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/sengem | |
dc.identifier.rssinternalid | 211422 | |
dc.identifier.doi | http://dx.doi.org/10.1117/12.2525246 | |
dc.rights.ecaccessrights | openAccess | |
dc.contributor.sponsor | Science Foundation Ireland | en |
dc.contributor.sponsorGrantNumber | IvP 13/IA/1894 | en |