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dc.contributor.authorSenge, Mathias
dc.contributor.authorCallaghan, Susan
dc.contributor.authorFilatov, Mikhail A.
dc.contributor.authorSavoie, Huguette
dc.contributor.authorBoyle, Ross W.
dc.date.accessioned2020-02-05T11:51:15Z
dc.date.available2020-02-05T11:51:15Z
dc.date.issued2019
dc.date.submitted2019en
dc.identifier.citationCallaghan, S., Filatov, M.A., Savoie, H., Boyle, R.W. & Senge, M.O., A lead BODIPY-phenylanthracene dyad for application in photodynamic therapy, 2019, Proceedings of SPIE - The International Society for Optical Engineering, 11070, 110709Ien
dc.identifier.otherY
dc.identifier.urihttps://www.spiedigitallibrary.org/conference-proceedings-of-spie/11070/2525246/A-lead-BODIPY-phenylanthracene-dyad-for-application-in-photodynamic-therapy/10.1117/12.2525246.short?SSO=1
dc.identifier.urihttp://hdl.handle.net/2262/91453
dc.description.abstractOver the past four years we have developed BODIPY dyads capable of triplet state generation from a charge transfer states generated by photoinduced electron transfer. In the current work we identify a lead compound for application in photodynamic therapy. This system is composed of a phenylanthracene electron donor unit and a dimethyl-substituted BODIPY acceptor unit. We have demonstrated that this compound, in submicromolar concentrations, can effectively generate singlet oxygen in polar solvents and induce cytotoxicity in human breast cancer cells (MDA-MB-468) when exposed to light. The photophysical properties of these compounds are chemically tunable and thus open the door not only to a new class of photodynamic therapy photosensitizers but also agents for triplet-triplet annihilation up-conversion applicationsen
dc.language.isoenen
dc.relation.ispartofseriesProceedings of SPIE - The International Society for Optical Engineering;
dc.relation.ispartofseries11070;
dc.relation.ispartofseries110709I;
dc.rightsYen
dc.subjectBODIPYen
dc.subjectPhotodynamic therapyen
dc.subjectTriplet stateen
dc.subjectSinglet oxygenen
dc.subjectPhotosensitizeren
dc.titleA lead BODIPY-phenylanthracene dyad for application in photodynamic therapyen
dc.typeConference Paperen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengem
dc.identifier.rssinternalid211422
dc.identifier.doihttp://dx.doi.org/10.1117/12.2525246
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberIvP 13/IA/1894en


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