A lead BODIPY-phenylanthracene dyad for application in photodynamic therapy
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Conference PaperDate:
2019Access:
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Callaghan, S., Filatov, M.A., Savoie, H., Boyle, R.W. & Senge, M.O., A lead BODIPY-phenylanthracene dyad for application in photodynamic therapy, 2019, Proceedings of SPIE - The International Society for Optical Engineering, 11070, 110709IDownload Item:
MS348_RSS (prepublication).pdf (Pre-print (author's copy) - Non-Peer Reviewed) 393.1Kb
Abstract:
Over the past four years we have developed BODIPY dyads capable of triplet state generation from a charge transfer
states generated by photoinduced electron transfer. In the current work we identify a lead compound for application in
photodynamic therapy. This system is composed of a phenylanthracene electron donor unit and a dimethyl-substituted
BODIPY acceptor unit. We have demonstrated that this compound, in submicromolar concentrations, can effectively
generate singlet oxygen in polar solvents and induce cytotoxicity in human breast cancer cells (MDA-MB-468) when
exposed to light. The photophysical properties of these compounds are chemically tunable and thus open the door not
only to a new class of photodynamic therapy photosensitizers but also agents for triplet-triplet annihilation up-conversion
applications
URI:
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11070/2525246/A-lead-BODIPY-phenylanthracene-dyad-for-application-in-photodynamic-therapy/10.1117/12.2525246.short?SSO=1http://hdl.handle.net/2262/91453
Sponsor
Grant Number
Science Foundation Ireland
IvP 13/IA/1894
Author's Homepage:
http://people.tcd.ie/sengemType of material:
Conference PaperURI:
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11070/2525246/A-lead-BODIPY-phenylanthracene-dyad-for-application-in-photodynamic-therapy/10.1117/12.2525246.short?SSO=1http://hdl.handle.net/2262/91453
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Series/Report no:
Proceedings of SPIE - The International Society for Optical Engineering;11070;
110709I;
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Full text availableKeywords:
BODIPY, Photodynamic therapy, Triplet state, Singlet oxygen, PhotosensitizerDOI:
http://dx.doi.org/10.1117/12.2525246Licences: