The effect of excercise and pioglitazone on the dynamic responses of oxygen uptake and leg vascular conductance in males with type 2 diabetes
Citation:
Eamonn O'Connor, 'The effect of excercise and pioglitazone on the dynamic responses of oxygen uptake and leg vascular conductance in males with type 2 diabetes', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2012, pp 360Download Item:
Abstract:
The exercise capacity of an individual with T2D is often reduced due to the
effects of T2D upon oxygen consumption- (VO2) and vascular conductance (VC)-
kinetics. Exercise training has been shown to induce improvements in the V O2-kinetic
and the VC-kinetic responses of individuals with T2D. Rosiglitazone use in T2D has
resulted improvements in V O2peak in individuals with T2D, although it did not result
in improvements in V O2 kinetics. However, no study has yet investigated the effects
of treatment with pioglitazone (PIO) on measures of V O2peak, VO2 kinetic or VC
kinetic responses. It has been shown that treatment with PIO induces similar effects
on endothelial function as rosiglitazone, therefore PIO treatment may induce similar
improvements in exercise performance.
Author: O'Connor, Eamonn
Advisor:
Egana, MikelQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of PhysiologyNote:
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Full text availableKeywords:
Physiology, Ph.D., Ph.D. Trinity College Dublin.Metadata
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