Computational investigation into the mechanoregulation of osteoporosis
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2009Author:
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Bríanne Mary Claire Mulvihill, 'Computational investigation into the mechanoregulation of osteoporosis', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009, pp 195Abstract:
Trabecular bone remodelling involves the continual resorption and formation of
bone along the surface of a strut. Experimental studies have shown that mechanical
stimuli, such as strain and damage, initiate and regulate this biological process.
The aim of this thesis is to develop a mechanoregulation algorithm, based on both
strain and damage stimuli, and to investigate whether such an algorithm is capable
of simulating the bone remodelling cycle along a trabecular strut. Following on
from this, the changes occurring to the process that lead to rapid and irreversible
loss of bone, as observed in skeletal diseases such as osteoporosis, were investigated.
Author: Mulvihill, Bríanne Mary Claire
Advisor:
Prendergast, P.JQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing EngineeringNote:
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