Regulators of inflammation and innate immunity identified in oesophageal cancer cell viability through implementation of a druggable genome siRNA library screen
Citation:
Catherine E. Garry, 'Regulators of inflammation and innate immunity identified in oesophageal cancer cell viability through implementation of a druggable genome siRNA library screen', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015, pp 395Download Item:
Abstract:
Inflammation initiated by gastroesophageal reflux disease (GORD) can lead to
development of oesophageal adenocarcinoma (OAC), through a premalignant lesion,
Barrett's oesophagus (BO). OAC has a 5-year survival of patients with localised OAC
of 38%, which decreases dramatically if the tumour has spread. Due to the
heterogeneity observed within cancers, identification of successful therapeutics has
proved difficult. Small interfering RNAs (siRNA) may be targeted to induce gene
silencing and subsequent loss of protein expression and function. Commercially
available siRNA libraries enable simultaneous analysis of the effect of thousands of
genes on a particular outcome. This study aimed to define therapeutic targets for OAC
by utilising a siRNA library screening with the intention of identifying novel
therapeutic targets for the treatment of OAC.
Author: Garry, Catherine E.
Advisor:
Kelleher, DermotQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MedicineNote:
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Medicine, Ph.D., Ph.D. Trinity College Dublin.Metadata
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