Current perspectives on the interleukin-1 family as targets for inflammatory disease.
File Type:
PDFItem Type:
Journal ArticleDate:
2019Access:
openAccessCitation:
Hernandez-Santana YE, Giannoudaki E, Leon G, Lucitt MB, Walsh PT., Current perspectives on the interleukin-1 family as targets for inflammatory disease., European journal of immunology, 2019Abstract:
Since the first description of interleukin-1 (IL-1) and the genesis of the field of cytokine
biology, the understanding of how IL-1 and related cytokines play central orchestrat-
ing roles in the inflammatory response has been an area of intense investigation. As a
consequence of these endeavours, specific strategies have been developed to target the
function of the IL-1 family in human disease realizing significant impacts for patients.
While the most significant advances to date have been associated with inhibition of the
prototypical family members IL-1α/β, approaches to target more recently identified family members such as IL-18, IL-33 and the IL-36 subfamily are now beginning to come
to fruition. This review summarizes current knowledge surrounding the roles of the IL-
1 family in human disease and describes the rationale and strategies which have been
developed to target these cytokines to inhibit the pathogenesis of a wide range of diseases
in which inflammation plays a centrally important role.
URI:
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201848056http://hdl.handle.net/2262/89335
Author's Homepage:
http://people.tcd.ie/walshp10http://people.tcd.ie/lucittm
Description:
PUBLISHED
Author: Walsh, Patrick; Lucitt, Margaret
Type of material:
Journal ArticleURI:
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201848056http://hdl.handle.net/2262/89335
Collections
Series/Report no:
European journal of immunologyAvailability:
Full text availableKeywords:
Canakinumab, Inflammation, Inflammatory disease, Interleukin-1 family, TherapyDOI:
http://dx.doi.org/10.1002/eji.201848056Metadata
Show full item recordLicences: