Show simple item record

dc.contributor.authorBourke, Nollaig
dc.contributor.authorStevenson, Nigel
dc.date.accessioned2019-08-13T14:29:50Z
dc.date.available2019-08-13T14:29:50Z
dc.date.issued2018
dc.date.submitted2018en
dc.identifier.citationBourke, NM, Napoletano, S, Bannan, C, Ahmed, S, Bergin C, McKnight, A, Stevenson, NJ. Control of HIV infection by IFN-α: implications for latency and a cure, Cellular and molecular life sciences : CMLS, 75, 5, 2018, 775-783en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/89183
dc.descriptionPUBLISHEDen
dc.description.abstractViral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence suggests that type I IFNs, in particular IFN-α, play a pivotal role in limiting acute HIV infection. Highly active antiretroviral treatment reduces viral load and increases life expectancy in HIV positive patients; however, it fails to fully eliminate latent HIV reservoirs. To revisit HIV as a curable disease, this article reviews a body of literature that highlights type I IFNs as mediators in the control of HIV infection, with particular focus on the anti-HIV restriction factors induced and/or activated by IFN-α. In addition, we discuss the relevance of type I IFN treatment in the context of HIV latency reversal, novel therapeutic intervention strategies and the potential for full HIV clearance.en
dc.format.extent775-783en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartofseriesCellular and molecular life sciences : CMLS;
dc.relation.ispartofseries75;
dc.relation.ispartofseries5;
dc.rightsYen
dc.subjectHIVen
dc.subjectInterferonen
dc.subjectLatencyen
dc.subjectAnti-viralen
dc.subjectJAK/STATen
dc.subjectCureen
dc.titleControl of HIV infection by IFN-α: implications for latency and a cure.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/nbourke
dc.identifier.peoplefinderurlhttp://people.tcd.ie/stevennj
dc.identifier.rssinternalid178955
dc.identifier.doihttp://dx.doi.org/10.1007/s00018-017-2652-4
dc.rights.ecaccessrightsembargoedAccess
dc.date.ecembargoEndDate2068-03-01
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.orcid_id0000-0003-4313-6859
dc.subject.darat_thematicHealthen
dc.status.accessibleNen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record