dc.contributor.author | Bourke, Nollaig | |
dc.contributor.author | Stevenson, Nigel | |
dc.date.accessioned | 2019-08-13T14:29:50Z | |
dc.date.available | 2019-08-13T14:29:50Z | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018 | en |
dc.identifier.citation | Bourke, NM, Napoletano, S, Bannan, C, Ahmed, S, Bergin C, McKnight, A, Stevenson, NJ. Control of HIV infection by IFN-α: implications for latency and a cure, Cellular and molecular life sciences : CMLS, 75, 5, 2018, 775-783 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/89183 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence suggests that type I IFNs, in particular IFN-α, play a pivotal role in limiting acute HIV infection. Highly active antiretroviral treatment reduces viral load and increases life expectancy in HIV positive patients; however, it fails to fully eliminate latent HIV reservoirs. To revisit HIV as a curable disease, this article reviews a body of literature that highlights type I IFNs as mediators in the control of HIV infection, with particular focus on the anti-HIV restriction factors induced and/or activated by IFN-α. In addition, we discuss the relevance of type I IFN treatment in the context of HIV latency reversal, novel therapeutic intervention strategies and the potential for full HIV clearance. | en |
dc.format.extent | 775-783 | en |
dc.language.iso | en | en |
dc.publisher | Springer | en |
dc.relation.ispartofseries | Cellular and molecular life sciences : CMLS; | |
dc.relation.ispartofseries | 75; | |
dc.relation.ispartofseries | 5; | |
dc.rights | Y | en |
dc.subject | HIV | en |
dc.subject | Interferon | en |
dc.subject | Latency | en |
dc.subject | Anti-viral | en |
dc.subject | JAK/STAT | en |
dc.subject | Cure | en |
dc.title | Control of HIV infection by IFN-α: implications for latency and a cure. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/nbourke | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/stevennj | |
dc.identifier.rssinternalid | 178955 | |
dc.identifier.doi | http://dx.doi.org/10.1007/s00018-017-2652-4 | |
dc.rights.ecaccessrights | embargoedAccess | |
dc.date.ecembargoEndDate | 2068-03-01 | |
dc.subject.TCDTheme | Genes & Society | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.orcid_id | 0000-0003-4313-6859 | |
dc.subject.darat_thematic | Health | en |
dc.status.accessible | N | en |