Control of HIV infection by IFN-α: implications for latency and a cure.
Item Type:Journal Article
Embargo End Date:2068-03-01
Citation:Bourke, NM, Napoletano, S, Bannan, C, Ahmed, S, Bergin C, McKnight, A, Stevenson, NJ. Control of HIV infection by IFN-α: implications for latency and a cure, Cellular and molecular life sciences : CMLS, 75, 5, 2018, 775-783
10.1007%2Fs00018-017-2652-4.pdf (PDF) 880.6Kb
Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence suggests that type I IFNs, in particular IFN-α, play a pivotal role in limiting acute HIV infection. Highly active antiretroviral treatment reduces viral load and increases life expectancy in HIV positive patients; however, it fails to fully eliminate latent HIV reservoirs. To revisit HIV as a curable disease, this article reviews a body of literature that highlights type I IFNs as mediators in the control of HIV infection, with particular focus on the anti-HIV restriction factors induced and/or activated by IFN-α. In addition, we discuss the relevance of type I IFN treatment in the context of HIV latency reversal, novel therapeutic intervention strategies and the potential for full HIV clearance.
Type of material:Journal Article
Series/Report no:Cellular and molecular life sciences : CMLS;
Availability:Full text available