The role of glycosylation and sequence variation in the regulation of von Willebrand Factor plasma levels
Citation:Orla. Rawley, 'The role of glycosylation and sequence variation in the regulation of von Willebrand Factor plasma levels', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2014, pp 376
Rawley TCD THESIS 10449 The role.pdf (PDF) 184.8Mb
Von Willebrand Factor (VWF) is a multimeric plasma sialoglycoprotein that plays an important role in primary haemostasis by mediating platelet capture at sites of vascular injury. In the normal population, VWF plasma concentrations vary over a wide range (5-20μg/mL). Importantly, VWF glycosylation, and single amino acid substitutions in the VWF molecule, have both been shown to contribute to variation in plasma VWF levels by regulating VWF clearance. However the biological mechanism(s) involved have not been defined.
Author: Rawley, Orla.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology
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Type of material:thesis
Availability:Full text available