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dc.contributor.advisorO'Donnell, James
dc.contributor.authorRawley, Orla.
dc.date.accessioned2017-06-27T15:57:16Z
dc.date.available2017-06-27T15:57:16Z
dc.date.issued2014
dc.identifier.citationOrla. Rawley, 'The role of glycosylation and sequence variation in the regulation of von Willebrand Factor plasma levels', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2014, pp 376
dc.identifier.otherTHESIS 10449
dc.identifier.urihttp://hdl.handle.net/2262/80478
dc.description.abstractVon Willebrand Factor (VWF) is a multimeric plasma sialoglycoprotein that plays an important role in primary haemostasis by mediating platelet capture at sites of vascular injury. In the normal population, VWF plasma concentrations vary over a wide range (5-20μg/mL). Importantly, VWF glycosylation, and single amino acid substitutions in the VWF molecule, have both been shown to contribute to variation in plasma VWF levels by regulating VWF clearance. However the biological mechanism(s) involved have not been defined.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15986887
dc.subjectHaematology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe role of glycosylation and sequence variation in the regulation of von Willebrand Factor plasma levels
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 376
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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