Recent Submissions

  • Modulation of activated protein C (APC) anticoagulant and cytoprotective function 

    Ní Áinle, Fionnuala Bríd (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2011)
    Activated protein C (APC) is an anticoagulant glycoprotein that attenuates thrombin generation. Moreover, it has recently been demonstrated that APC possesses anti-inflammatory, anti-apoptotic and endothelial cell barrier ...
  • Variation in DNA repair genes XRCC3, XRCC4, and XRCC5 and susceptibility ot myeloma 

    Hayden, Patrick John (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2010)
    Cytogenetic analysis in myeloma reveals marked chromosomal instability. Both widespread genomic alterations and evidence of aberrant class switch recombination, the physiological process that regulates maturation of the ...
  • Role of membrane lipids and plasma lipoproteins in the regulation of activated protein C function 

    Johnson, Jennifer (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2013)
    Activated protein C (APC) is an important anticoagulant factor that serves to downregulate thrombin generation. APC also has several cytoprotective properties, including anti-apoptotic and endothelial barrier stabilizing ...
  • Molecular determinants of vitamin K-dependent protease signalling 

    Gleeson, Eimear M. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2013)
    In addition to facilitating fibrin clot formation, a growing body of evidence suggests that coagulation factors play an important role in regulating the innate immune response to infection. Vitamin K-dependent (VKD) proteases ...
  • Investigations into Pyrrolo-1,5-Benzoxazepine-15-induced apoptosis of chronic B-cell malignancies 

    Maginn, Elaina N. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2009)
    Multiple myeloma and chronic lymphocytic leukaemia (CLL) are chronic B-cell malignancies, which are characterised by the accumulation of malignant cells with low proliferative capacity and defective apoptotic mechanisms. ...

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