Haematology (Theses and Dissertations)
Recent Submissions
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Defining the mechanisms through which von willebrand factor sialic acid expression regulates in vivo clearance
(Trinity College Dublin. School of Medicine. Discipline of Haematology, 2019)Von Willebrand Factor (VWF) is a complex plasma sialoglycoprotein which plays a key role in maintaining normal haemostasis. While the biosynthesis, structure, and functions of VWF are well characterised, the molecular ... -
Investigating the Role of Von Willebrand Factor in Regulating Macrophage Biology and Innate Immunity
(Trinity College Dublin. School of Medicine. Discipline of Haematology, 2019)The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary haemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have suggested that VWF may ... -
Isolation and characterisation of a monocyte protein C receptor : implications for novel therapeutic strategies in sepsis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2003)The protein C (PC) pathway provides a unique interface between the processes of coagulation, inflammation and fibrinolysis. Used as an adjunct to standard treatment, PC/activated PC to date, has been shown to be the only ... -
The Role of STAT3 in the Pathogenesis of Chronic Lymphocytic Leukaemia
Chronic Lymphocytic Leukaemia (CLL) is characterized by the accumulation of CD5/19+ B cells in the blood, bone marrow and lymph nodes. The tumour microenvironment of the bone marrow and secondary lymphoid organs promotes ... -
An investigation into the potential use of Beta-Galactoside binding protein as a novel anti-leukaemic agent
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2005)Chronic myelogenous leukaemia (CML) is characterised at the molecular level by a (9;22) translocation which places the abl proto-oncogene under the control of the breakpoint cluster region (bcr) gene promoter generating a ... -
The role of glycosylation and sequence variation in the regulation of von Willebrand Factor plasma levels
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2014)Von Willebrand Factor (VWF) is a multimeric plasma sialoglycoprotein that plays an important role in primary haemostasis by mediating platelet capture at sites of vascular injury. In the normal population, VWF plasma ... -
Defining the roles of von Willebrand Factor and Factor V111 glycosylation in regulating lectin interaction and modulating in vivo clearance
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2015)von Willebrand Factor (VWF) is a large multimeric sialoglycoprotein which mediates critical roles in normal haemostasis. VWF tethers platelets at sites of vascular injury and also serves as a chaperone for coagulation ... -
Defining inherited haematological disease within the Irish traveller population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2006)The Traveller Community in Ireland constitutes a minority of nomadic or semi-nomadic people, sharing a common Irish ancestry. The Traveller Health Study showed that in 1987, Travellers were only reaching the life expectancy ... -
Cellular and molecular mechanisms associated with sensitivity to DNA damaging agents in various human genetic disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2005)The integrity of the genome is important to cellular and organism homeostasis. It is under constant threat due to intrinsic and extrinsic factors which contribute to a variety of genetic alterations and so genomic integrity ... -
Modulation of activated protein C (APC) anticoagulant and cytoprotective function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2011)Activated protein C (APC) is an anticoagulant glycoprotein that attenuates thrombin generation. Moreover, it has recently been demonstrated that APC possesses anti-inflammatory, anti-apoptotic and endothelial cell barrier ... -
Variation in DNA repair genes XRCC3, XRCC4, and XRCC5 and susceptibility ot myeloma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2010)Cytogenetic analysis in myeloma reveals marked chromosomal instability. Both widespread genomic alterations and evidence of aberrant class switch recombination, the physiological process that regulates maturation of the ... -
Role of membrane lipids and plasma lipoproteins in the regulation of activated protein C function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2013)Activated protein C (APC) is an important anticoagulant factor that serves to downregulate thrombin generation. APC also has several cytoprotective properties, including anti-apoptotic and endothelial barrier stabilizing ... -
Molecular determinants of vitamin K-dependent protease signalling
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2013)In addition to facilitating fibrin clot formation, a growing body of evidence suggests that coagulation factors play an important role in regulating the innate immune response to infection. Vitamin K-dependent (VKD) proteases ... -
Investigations into Pyrrolo-1,5-Benzoxazepine-15-induced apoptosis of chronic B-cell malignancies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2009)Multiple myeloma and chronic lymphocytic leukaemia (CLL) are chronic B-cell malignancies, which are characterised by the accumulation of malignant cells with low proliferative capacity and defective apoptotic mechanisms. ... -
Prostate cancer progression to androgen independence - do changes in the androgen receptor CAG repeat number play a role?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2007)Prostate cancer is the commonest non-cutaneous male malignancy and is the second commonest cause of cancer-related deaths in many Western countries. Approximately half of all men diagnosed with prostate cancer will have ... -
Genetic analysis of the human prohibitin gene (PHB) in breast and other cancers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2000)Prohibitin, an evolutionarily conserved gene situated on chromosome 17q21, was originally identified as a gene with antiproliferative properties. Studies of a Japanese population have shown prohibitin to be somatically ... -
The coagulation & inflammation interface : the pathophysiological basis for disease states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2003)The molecular and cellular pathways of coagulation and inflammation have traditionally been regarded as separate entities, however recent research has demonstrated that they are closely linked through endothelial and ... -
Prognostic factors in chronic lymphocytic leukemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world, accounting for nearly 24% of all leukaemias. It is estimated that 7300 new cases were diagnosed in 2003 in the United States and there ... -
Drug-induced veno-occlusive disease of the liver : unravelling the role of the inflammatory and coagulation pathways
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)The thiopurines thioguanine (6TG) and mercaptopurine (6MP), along with Mylotarg (an antibody targeted agent), are used in the treatment of acute leukaemias. These drugs are more commonly associated with the development of ... -
Detection of minimal residual disease and WT1 overexpression in childhood acute leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Minimal residual disease (MRD), the post-treatment presence of a small submicroscopic amount of leukaemic cells in the bone marrow or other sites undetectable by conventional methods, has been recently shown to be one of ...