Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation
Citation:
Shane O'Sullivan, 'Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014, pp 278Abstract:
Inflammatory bowel disease is characterised by a dysregulated immune response and a compromised epithelial barrier. The enzyme matrix metalloproteinase-9 (MMP-9) is upregulated in an inflammatory setting and is believed to contribute to the pathogenesis of the disease. Nitric oxide is a gaseous signalling molecule with an, as of yet, unknown regulatory effect on MMP-9. Organic nitrates have been used as NO donors or mimetics to take advantage of NO’s pharmacological effects, but never as part of a hybrid to inhibit an MMP. The aims of my project were to synthesise and test the ability of a series of nitrate- barbiturate compounds to inhibit MMP-9 in both in-vitro and in-vivo models of intestinal inflammation and to determine the contribution of the nitrate moiety in this inhibition.
Author: O'Sullivan, Shane
Advisor:
Medina Martin, CarlosGilmer, John
Qualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical SciencesNote:
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Full text availableKeywords:
Pharmacology, Ph.D., Ph.D. Trinity College DublinMetadata
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