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dc.contributor.advisorMedina Martin, Carlos
dc.contributor.advisorGilmer, John
dc.contributor.authorO'Sullivan, Shane
dc.date.accessioned2017-06-27T14:18:27Z
dc.date.available2017-06-27T14:18:27Z
dc.date.issued2014
dc.identifier.citationShane O'Sullivan, 'Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014, pp 278
dc.identifier.otherTHESIS 10793
dc.identifier.urihttp://hdl.handle.net/2262/80458
dc.description.abstractInflammatory bowel disease is characterised by a dysregulated immune response and a compromised epithelial barrier. The enzyme matrix metalloproteinase-9 (MMP-9) is upregulated in an inflammatory setting and is believed to contribute to the pathogenesis of the disease. Nitric oxide is a gaseous signalling molecule with an, as of yet, unknown regulatory effect on MMP-9. Organic nitrates have been used as NO donors or mimetics to take advantage of NO’s pharmacological effects, but never as part of a hybrid to inhibit an MMP. The aims of my project were to synthesise and test the ability of a series of nitrate- barbiturate compounds to inhibit MMP-9 in both in-vitro and in-vivo models of intestinal inflammation and to determine the contribution of the nitrate moiety in this inhibition.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb16204390
dc.subjectPharmacology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleNitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 278
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