RSS 1.0Pharmacy and Pharmaceutical Sciences (Theses and Dissertations)
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Chemical biology studies on human and mouse secondary bile acids
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Bile acids are important regulators of multiple homeostatic mechanisms integrating cell proliferation, metabolism and inflammation. The overall objective of this thesis was to use chemical biology tools to understand ... -
Investigations of extracellular vesicles in triple-negative breast cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Breast cancer is the most commonly diagnosed cancer worldwide accounting for 11.7% of the newly diagnosed 19.3 million cases in 2020. In Ireland breast cancer accounted for 10.8% of cancer cases and 23.8% of female cancers. ... -
A Scientific Evaluation of Traditional Chinese Medicine (TCM): Houttuynia cordata Thunb Saururaceae - A Case Study
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Traditional Chinese Medicine (TCM) is one of the oldest medical systems in the world, still used for prevention or treatment of diseases in the modern China. It is a unique and holistic system, guided by ancient Chinese ... -
C6 glioma neuronal interactions and their moderation by the tryptophan-kynurenine metabolism pathway
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Brain glia possess the rate limiting enzyme indoleamine 2, 3-dioxygenase (IDO) which catalyses the conversion of tryptophan to kynurenine. Microglia also express kynurenine monooxygenase (KMO) and kynureninase (KYNU) which ... -
Design and development of a hydrogel formulation with nanoparticles for the treatment of glioblastoma multiforme
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Glioblastoma multiforme (GBM) is the most aggressive form of brain tumours. GBM treatment is challenging because tumours are highly invasive and it is difficult to achieve effective therapeutic doses of drugs into the ...
