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  Receptor tyrosine kinases and drug resistance: development and characterization of in vitro models of resistance to RTK inhibitors. 

  O'Driscoll, Lorraine (2015)

  Aberrant expression of receptor tyrosine kinases (RTKs) has been extensively associated with alterations in the physiological activities of cells. These include cell growth and differentiation, cell death/survival, and the ...
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  Targeting glial B2-adrenoceptors for immunododulation & neuoprotection in a rat model of Parkinson's disease 

  O'NEILL, EOIN (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)

  Neuro-inflammation is a key contributor to the pathogenesis of Parkinson’s disease (PD). Brain-resident microglia are dynamic cellular effectors of inflammation-mediated neurodegeneration in the Parkinsonian brain. Here ...
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  The production and characterisation of itraconazole multicomponent systems 

  KOZYRA, AGNIESZKA IRENA (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)

  This thesis focuses on the poorly soluble triazole antifungal agent, itraconazole (ITZ). This compound was reported to form hydrochloride salts and cocrystals with a wide range of aliphatic dicarboxylic acids, which have ...
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  Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles 

  LOWRY, MICHELLE (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)

  Breast cancer is the most common female cancer diagnosed worldwide. In 2018 alone, there were over 2 million new breast cancer cases diagnosed. In Ireland, breast cancer is the most commonly diagnosed cancer in women. In ...
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  Synthesis of Tubulin Inhibitors with Variable Molecular Hinges for the Attachment of Aminopeptidase N Targeting Moieties 

  ANWAR, ZEESHAN (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)

  This thesis includes synthesis of various tubulin binding agents and their incorporation in to novel dual acting hybrids, which along with the tubulin inhibition also exhibit aminopeptidase N (APN) inhibition activities. This ...

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