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Recent Submissions
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In vivo and in vitro mechanistic studies on targeting of lipophilic compounds to the intestinal lymphatics using lipid-based vehicles
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The aim of the experiments conducted in this thesis was to investigate the effect of a range of lipid-based vehicles on the intestinal lymphatic transport of triglycerides and of two lipophilic compounds- DDT and cyclosporine, ... -
Preparation of cocrystal-in-excipient systems by advanced pharmaceutical methods
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the production of cocrystal-in-excipient systems by a variety of advanced pharmaceutical methods, such as spray drying, hot melt extrusion and spray coating. The production of cocrystal-in-excipient ... -
The production, characterisation, stabilization and isolation of azole anti-fungal nanoparticles
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredients (APIs): itraconazole (ITR), ketoconazole ... -
Receptor tyrosine kinases and drug resistance: development and characterization of in vitro models of resistance to RTK inhibitors.
(2015)Aberrant expression of receptor tyrosine kinases (RTKs) has been extensively associated with alterations in the physiological activities of cells. These include cell growth and differentiation, cell death/survival, and the ... -
Targeting glial B2-adrenoceptors for immunododulation & neuoprotection in a rat model of Parkinson's disease
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Neuro-inflammation is a key contributor to the pathogenesis of Parkinson’s disease (PD). Brain-resident microglia are dynamic cellular effectors of inflammation-mediated neurodegeneration in the Parkinsonian brain. Here ...
