The role of HIF-lalpha and hypoxia in the preferential response of prostate tumours to microtubule-targeting agents
Citation:
James Christopher Forde, 'The role of HIF-lalpha and hypoxia in the preferential response of prostate tumours to microtubule-targeting agents', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010, pp 132Download Item:
Abstract:
Tumour hypoxia is emerging as a common feature of prostate tumours associated with poor prognosis mainly due to their resistance to chemo- radiotherapy regimes. The efficacy of microtubule-targeting agents (MTAs) has recently been shown to be modulated by Hypoxia-Inducible-Factor-1 alpha (HIF-1α). HIF- 1α over expression has been reported to occur in almost 70% of all human tumours including prostate cancer.
Author: Forde, James Christopher
Advisor:
Lawler, MarkQualification name:
Doctor of Medicine (M.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MedicineNote:
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