dc.contributor.author | FALLON, PADRAIC | en |
dc.contributor.author | SHEILS, ORLA | en |
dc.contributor.author | HAMS, EMILY | en |
dc.date.accessioned | 2017-04-20T09:43:20Z | |
dc.date.available | 2017-04-20T09:43:20Z | |
dc.date.issued | 2015 | en |
dc.date.submitted | 2015 | en |
dc.identifier.citation | Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG., Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells., European Journal of Immunology, 2015 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/79862 | |
dc.description | PUBLISHED | en |
dc.description.abstract | B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. Previous work has identified an expansion of these cells in mice infected with the helminth, Schistosoma mansoni. Here, microarray analysis of CD19(+) CD1d(hi) B cells from mice infected with S. mansoni demonstrated significantly increased Tlr7 expression, while CD19(+) CD1d(hi) B cells from uninfected mice also demonstrated elevated Tlr7 expression. Using IL-10 reporter, Il10(-/-) and Tlr7(-/-) mice, we formally demonstrate that TLR7 ligation of CD19(+) CD1d(hi) B cells increases their capacity to produce IL-10. In a mouse model of allergic lung inflammation, the adoptive transfer of TLR7-elicited CD19(+) CD1d(hi) B cells reduced airway inflammation and associated airway hyperresponsiveness. Using DEREG mice to deplete FoxP3(+) T regulatory cells in allergen-sensitized mice, we show that that TLR7-elicited CD19(+) CD1d(hi) B cells suppress airway hyperresponsiveness via a T regulatory cell dependent mechanism. These studies identify that TLR7 stimulation leads to the expansion of IL-10-producing CD19(+) CD1d(hi) B cells, which can suppress allergic lung inflammation via T regulatory cells. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | European Journal of Immunology | en |
dc.rights | Y | en |
dc.subject | Genetics | en |
dc.title | Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/pfallon | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/osheils | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/hamse | en |
dc.identifier.rssinternalid | 106887 | en |
dc.identifier.doi | http://dx.doi.org/10.1002/eji.201445211 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.orcid_id | 0000-0002-8401-7293 | en |