Microtubule associated signal transduction processes in t-cell migration
Citation:
Navin Kumar Verma, 'Microtubule associated signal transduction processes in t-cell migration', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010, pp 299Download Item:
Abstract:
The ordered, directional migration of T-lymphocytes is a key process during immune surveillance, and immune response. T-cell migration is a complex, highly coordinated process. This requires cell adhesion to the high endothelial venules or to the extracellular matrix by a series of surface receptor/ligand interactions involving adhesion molecules of the integrin family including lymphocyte function associated molecule-1 (LFA-1), phosphorylation- dependent signalling cascades and cytoskeletal rearrangements. Mechanisms that regulate T-cell migration are of considerable relevance for understanding the pathogenesis of various diseases including chronic inflammatory diseases such as inflammatory bowel disease and the inflammatory arthropathies.
Author: Verma, Navin Kumar
Advisor:
Volkov, YuriQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MedicineNote:
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