The role of insulin-like growth factor 1 receptor (IGF-IR) in non-small cell lung cancer (NSCLC)
Citation:
Lydia Forde, 'The role of insulin-like growth factor 1 receptor (IGF-IR) in non-small cell lung cancer (NSCLC)', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012, pp 266Download Item:
Abstract:
Lung cancer is the most common cause of cancer related death in Ireland and worldwide. Despite modest advances in traditional cytotoxic chemotherapy, survival rates remain disappointing at approximately 15%. Targeted therapies such as EGFR tyrosine kinase inhibitors (TKIs) provide some improvement in clinical outcomes. However the development of resistance to these drugs remains a major problem in the treatment of cancer. The rationale for investigating new targeted agents and the use of combination therapies is clear.
Author: Forde, Lydia
Advisor:
Gately, KathyQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MedicineNote:
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