Impact of pro-inflammatory cytokines on glucocorticoid sensitivity, kynurenine pathway and serotonin transport in microglia : implications for depression and the anti-inflammatory actions of antidepressants
Citation:
Eimear Fagan, 'Impact of pro-inflammatory cytokines on glucocorticoid sensitivity, kynurenine pathway and serotonin transport in microglia : implications for depression and the anti-inflammatory actions of antidepressants', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2013, pp 243Download Item:
Abstract:
Neuroinflammation is known to be a major contributing factor to neurodegeneration and has been implicated in neuropsychiatric diseases such as major depression. Microglia are the immunocompetent cells of the CNS and are the main source of inflammatory cytokines in the brain. In the present investigation three potential mechanisms linking inflammatory mediators to microglial activation and function of relevance to neuropsychiatric disorders were explored namely (i) glucocorticoid (GC) signalling (ii) activation of tryptophan metabolism through the kynurenine pathway (KP) and (iii) monoamine transport and metabolism.
Author: Fagan, Eimear
Advisor:
Connor, ThomasQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of PhysiologyNote:
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Full text availableKeywords:
Physiology, Ph.D., Ph.D. Trinity College DublinMetadata
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