Modulation of microglial phenotypes by CD200
Citation:
Stephanie Denieffe, 'Modulation of microglial phenotypes by CD200', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2012, pp 207Download Item:
Abstract:
Microglia are the principal immune cells of the CNS continually surveying their micro-environment for endogenous and exogenous stimuli which may threaten the immunological balance. Recent studies have suggested that activated microglia, like macrophages, adopt different phenotypes depending on the stimulus; IFNy induces classical activation of microglia, whereas IL-4 induces an alternative activation state. A deactivation state has been described in which the interaction between ligand-receptor pairs, for example CD200-CD200R, suppress the immune response. The focus of this study was to investigate the modulatory role of CD200 on different microglial phenotypes.
Author: Denieffe, Stephanie
Advisor:
Lynch, MarinaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of PhysiologyNote:
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Physiology, Ph.D., Ph.D. Trinity College DublinMetadata
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