Inherited variation in the xenobiotic response system in inflammatory bowel disease
Citation:
Megan Dring, 'Inherited variation in the xenobiotic response system in inflammatory bowel disease', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007, pp 271Download Item:
Abstract:
The aim of this study was to further the understanding regarding the genetic background of Inflammatory Bowel Disease (IBD). IBD patients can be classified into two major phenotypes, Crohn’s disease (CD) and ulcerative colitis (UC), both of which are thought to result from the complex interplay of multiple genetic and environmental factors in genetically predisposed individuals. Evidence from several studies suggests that the xenobiotic metabolism system may play a role in IBD. We therefore investigated the inheritance of polymorphisms in genes involved in the xenobiotic response system in a population of IBD patients and healthy controls. To this aim, the association of functional polymorphisms of the nuclear receptors, PXR, CAR, FXR and RXRa, and the xenobiotic metabolising enzymes, MDR1 and MRP3, with disease in IBD populations was examined.
Author: Dring, Megan
Advisor:
McManus, RossQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MedicineNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ieType of material:
thesisCollections
Availability:
Full text availableMetadata
Show full item recordLicences: