Does IL-1F5 have anti-inflammatory actions in the brain?
Citation:Céire E. Costelloe, 'Does IL-1F5 have anti-inflammatory actions in the brain?', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2007, pp 269
Costelloe TCD THESIS 8296 Does IL1F5.pdf (PDF) 146.0Mb
Similarity in structure and sequence homology has led to the identification of additional members of the IL-1 ligand and receptor superfamilies. Because of the importance of IL-1 in immune and inflammatory reactions, elucidation of the respective roles of these recently described members is a priority. Thus far identification of a biological role for IL-1F5 has remained elusive. In this thesis investigation into a possible role for IL-1F5 in neuronal tissue was carried out and the findings of this study suggest that IL-1F5 abrogates IL-1β-induced inhibition of Long term potentiation (LTP), and associated increase in activation of c-Jun N terminal kinase (JNK). The data also show that IL-1F5 antagonizes the inhibitory effect of lipopolysaccharide (LPS) on LTP in rat dentate gyrus. The data indicate that this is associated with its ability to inhibit the LPS-induced activation of microglial cells and, as a consequence inhibit the increase in IL-1β and JNK.
Author: Costelloe, Céire E.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). Department of Physiology
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Type of material:thesis
Availability:Full text available