dc.contributor.author | WINDLE, HENRY | en |
dc.date.accessioned | 2016-06-21T11:38:50Z | |
dc.date.available | 2016-06-21T11:38:50Z | |
dc.date.issued | 2014 | en |
dc.date.submitted | 2014 | en |
dc.identifier.citation | D Jaganath, M Saito, RH Gilman, V Cama, L Cabrera, D Kelleher, H Windle, J Crabtree, W Checkley, First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru, Helicobacter, 2014 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/76564 | |
dc.description.abstract | BACKGROUND:
In endemic settings, Helicobacter pylori infection can occur shortly after birth and may be associated with a reduction in childhood growth.
MATERIALS AND METHODS:
This study investigated what factors promote earlier age of first H. pylori infection and evaluated the role of H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) on height. We included 183 children near birth from a peri-urban shanty town outside of Lima, Peru. Field-workers collected data on socioeconomic status (SES), daily diarrheal and breast-feeding history, antibiotic use, anthropometrics, and H. pylori status via carbon 13-labeled urea breath test up to 24 months after birth. We used a proportional hazards model to assess risk factors for earlier age at first detected infection and linear mixed-effects models to evaluate the association of first detected H. pylori infection during infancy on attained height.
RESULTS:
One hundred and forty (77%) were infected before 12 months of age. Lower SES was associated with earlier age at first detected H. pylori infection (low vs middle-to-high SES Hazard ratio (HR) 1.59, 95% CI 1.16, 2.19; p = .004), and greater exclusive breast-feeding was associated with reduced likelihood (HR 0.63, 95% CI 0.40, 0.98, p = .04). H. pylori infection in infancy was not independently associated with growth deficits (p = .58). However, children who had their first detected H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) and who had an average number of diarrhea episodes per year (3.4) were significantly shorter at 24 months (-0.37 cm, 95% CI, -0.60, -0.15 cm; p = .001).
DISCUSSION:
Lower SES was associated with a higher risk of first detected H. pylori infection during infancy, which in turn augmented the adverse association of diarrheal disease on linear growth. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Helicobacter | en |
dc.rights | Y | en |
dc.subject | Helicobacter pylori | en |
dc.title | First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/hjwindle | en |
dc.identifier.rssinternalid | 93221 | en |
dc.relation.ecprojectid | info:eu-repo/grantAgreement/EC/FP7/INCO-CT-2006-032136 | |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Cancer | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.subject.TCDTheme | International Development | en |
dc.contributor.sponsor | European Union (EU) | en |
dc.contributor.sponsorGrantNumber | INCO-CT-2006-032136 | en |