Presymptomatic and longitudinal neuroimaging in neurodegeneration: from snapshots to motion picture - a systematic review
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2015Access:
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Schuster C, Elamin M, Hardiman O, Bede P, Presymptomatic and longitudinal neuroimaging in neurodegeneration: from snapshots to motion picture - a systematic review, J Neurol Neurosurg Psychiatry, 2015Download Item:
J Neurol Neurosurg Psychiatry-2015-Schuster-jnnp-2014-309888.pdf (Published (author's copy) - Peer Reviewed) 584.8Kb
Abstract:
Background
Recent quantitative neuroimaging studies
have been successful in capturing phenotype and
genotype-speci
fi
c changes in dementia syndromes,
amyotrophic lateral sclerosis, Parkinson
’
s disease and
other neurodegenerative conditions. However, the
majority of imaging studies are cross-sectional, despite
the obvious superiority of longitudinal study designs in
characterising disease trajectories, response to therapy,
progression rates and evaluating the presymptomatic
phase of neurodegenerative conditions.
Objectives
The aim of this work is to perform a
systematic review of longitudinal imaging initiatives in
neurodegeneration focusing on methodology, optimal
statistical models, follow-up intervals, attrition rates,
primary study outcomes and presymptomatic studies.
Methods
Longitudinal imaging studies were identi
fi
ed
from
‘
PubMed
’
and reviewed from 1990 to 2014. The
search terms
‘
longitudinal
’
,
‘
MRI
’
,
‘
presymptomatic
’
and
‘
imaging
’
were utilised in combination with one of the
following degenerative conditions; Alzheimer
’
s disease,
amyotrophic lateral sclerosis/motor neuron disease,
frontotemporal dementia, Huntington
’
s disease, multiple
sclerosis, Parkinson
’
s disease, ataxia, HIV, alcohol abuse/
dependence.
Results
A total of 423 longitudinal imaging papers
and 103 genotype-based presymptomatic studies were
identi
fi
ed and systematically reviewed. Imaging
techniques, follow-up intervals and attrition rates
showed signi
fi
cant variation depending on the primary
diagnosis. Commonly used statistical models included
analysis of annualised percentage change, mixed and
random effect models, and non-linear cumulative models
with acceleration
–
deceleration components.
Discussion and conclusions
Although longitudinal
imaging studies have the potential to provide crucial
insights into the presymptomatic phase and natural
trajectory of neurodegenerative processes a standardised
design is required to enable meaningful data
interpretation
Sponsor
Grant Number
European Union Framework Programme 7 (FP7)
Health Research Board (HRB)
Author's Homepage:
http://people.tcd.ie/hardimaohttp://people.tcd.ie/pbede
Description:
IN_PRESS
Author: HARDIMAN, ORLA; BEDE, PETER
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J Neurol Neurosurg PsychiatryAvailability:
Full text availableKeywords:
neurodegenerative conditionsSubject (TCD):
Ageing , Genes & Society , Neuroscience , Next Generation Medical DevicesDOI:
http://dx.doi.org/10.1136/jnnp-2014-309888Licences: