Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.
Citation:
Riedel BM, Molloy AM, Meyer K, Fredriksen A, Ulvik A, Schneede J, Nexø E, Hoff G, Ueland PM, Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women., The Journal of nutrition, 141, 10, 2011, 1784-90Download Item:
Abstract:
Two polymorphic variants in the gene coding for transcobalamin II (
TCN2
),
TCN2
776C-
.
Gand
TCN2
67A-
.
G, may alter
serum holotranscobalamin (holoTC), which in turn may affect cellular uptake of cobalamin (Cbl) and thereby Cbl status
indicators. We studied the effects of
TCN2
776C-
.
Gand
TCN2
67A-
.
G on blood concentrations of holoTC, Cbl,
methylmalonic acid (MMA), and total homocysteine (tHcy) in 2411 individuals (50–64 y) that had been selected on the basis
of these
TCN2
genotypes from 10601 Norwegian inhabitants. The serum holoTC concentration was lower in
TCN2
67AG
(55
6
0.75 pmol/L) and 67GG (48
6
2.14 pmol/L) than in 67AA (62
6
0.67 pmol/L) (
P
,
0.001) but did not differ among
TCN2
776C-
.
G genotypes. The polymorphisms interacted as serum holoTC determinants (
P
= 0.001) and the presence of
TCN2
67AG and GG in strata of 776CC and CG, but not 776GG, increased the risk of having serum holoTC
,
45.6 pmol/L [tertile
1 vs. tertiles 2 and 3: OR = 2.5 (95% CI 1.8–3.5) for 67AG; OR = 5.7 (95% CI 3.5–9.1) for 67GG in 776CC; OR = 2.1 (95% CI
1.6–2.9) for 67AG; and OR = 4.5 (95% CI 2.4–8.2) for 67GG in 776CG; all
P
,
0.001]. Plasma MMA, tHcy, and Cbl were not
affected by either polymorphism. In summary, serum holoTC, but not plasma Cbl, MMA, or tHcy, varied according to
TCN2
67A-
.
G genotypes. It remains to be determined whether this polymorphic effect on serum holoTC alters its diagnostic utility
as Cbl status indicator. J. Nutr. 141: 1784–1790, 2011.
Author's Homepage:
http://people.tcd.ie/amolloyDescription:
PUBLISHED
Author: MOLLOY, ANNE
Type of material:
Journal ArticleCollections
Series/Report no:
The Journal of nutrition141
10
Availability:
Full text availableKeywords:
transcobalamin IISubject (TCD):
Genes & SocietyDOI:
http://dx.doi.org/10.3945/jn.111.141960ISSN:
0022-3166Metadata
Show full item recordLicences: