dc.contributor.author | FALLON, PADRAIC | en |
dc.contributor.author | HAMS, EMILY | en |
dc.date.accessioned | 2014-11-24T12:20:51Z | |
dc.date.available | 2014-11-24T12:20:51Z | |
dc.date.issued | 2014 | en |
dc.date.submitted | 2014 | en |
dc.identifier.citation | Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN., MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion., Immunity, 41, 2014, 283 - 295 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/72134 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCII-expressing ILC2s interact with antigen-specific T cells to instigate a dialog in which IL-2 production from T cells promotes ILC2 proliferation and IL-13 production. Deletion of MHCII renders IL-13-expressing ILC2s incapable of efficiently inducing Nippostrongylus brasiliensis expulsion. Thus, during transition to adaptive T cell-mediated immunity, the ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production. This interaction appears to augment dendritic-cell-induced T cell activation and identifies a previously unappreciated pathway in the regulation of type-2 immunity. | en |
dc.format.extent | 283 | en |
dc.format.extent | 295 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Immunity | en |
dc.relation.ispartofseries | 41 | en |
dc.rights | Y | en |
dc.subject | Immunity | en |
dc.title | MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/pfallon | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/hamse | en |
dc.identifier.rssinternalid | 96665 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.rssother | PMID: 25088770 | en |
dc.subject.TCDTag | Biomedical sciences | en |
dc.identifier.orcid_id | 0000-0002-8401-7293 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |