Browsing Clinical Medicine by Sponsor "European Union Framework Programme 7 (FP7)"
Now showing items 1-8 of 8
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An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013)
(2014)Abstract Introduction There has been much interest in spatial analysis of ALS to identify potential environmental or genetically caused clusters of disease. Results to date have been inconclusive. The Irish ALS register ... -
Harmonic and superparamagnetic nanoparticles for biomedical imaging and diagnostic applications
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Diagnosing certain diseases and tracking their progression requires the ability to 'see' into the body. This is typically achieved by taking advantage of intrinsic contrast in biological tissues (such as in X-ray or magnetic ... -
Presymptomatic and longitudinal neuroimaging in neurodegeneration: from snapshots to motion picture - a systematic review
(2015)Background Recent quantitative neuroimaging studies have been successful in capturing phenotype and genotype-speci fi c changes in dementia syndromes, amyotrophic lateral sclerosis, Parkinson ’ s disease and other ... -
Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.
(2015)TLR4-activated macrophages switch their metabolism from oxidative phosphorylation to glycolysis to rapidly provide for the high energy and biosynthetic demands of infection or injury response. Palsson-McDermott identify ... -
Survival Analysis of Irish Amyotrophic Lateral Sclerosis Patients Diagnosed from 1995 2010
(2013)Introduction: The Irish ALS register is a valuable resource for examining survival factors in Irish ALS patients. Cox regression has become the default tool for survival analysis, but recently new classes of flexible ... -
Therapeutic outcomes, immunological responses to treatment and vaccine preventative strategies for Hepatitis C in HIV seropositive individuals
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Introduction: HIV and Hepatitis C virus (HCV) represent significant causes of morbidity and mortality worldwide. Because of shared routes of transmission co-infection is common. Recent advances in treatment for both ... -
Towards a nanospecific approach for risk assessment.
(2016)In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the ... -
What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis
(2017)Introduction: ALSFRS-R is the most widely used functional rating system in ALS patients. However, heterogeneity in ALSFRS-R progression renders analysis challenging. We have explored the characteristics of total ALSFRS-R, ...