Homocysteine, folate enzymes and neural tube defects
Citation:
A. M. Molloy, D. G. Weir and J. M. Scott, Homocysteine, folate enzymes and neural tube defects, Haematologica, 84 Suppl, EHA-4, 1999, 53-56Download Item:
Homocysteine levels.pdf (Published (publisher's copy) - Peer Reviewed) 256.3Kb
Abstract:
Background: The purpose of this study was to characterize total homocysteine (tHcy) levels at
birth in preterm and term infants and identify associations with intraventricular hemorrhage (IVH)
and other neonatal outcomes such as mortality, sepsis, necrotizing enterocolitis,
bronchopulmonary dysplasia, and thrombocytopenia.
Methods: 123 infants < 32 weeks gestation admitted to our Level III nursery were enrolled. A
group of 25 term infants were enrolled for comparison. Two blood spots collected on filter paper
with admission blood drawing were analyzed by a high performance liquid chromatography (HPLC)
method. Statistical analysis included ANOVA, Spearman's Rank Order Correlation and Mann-
Whitney U test.
Results: The median tHcy was 2.75 ?mol/L with an interquartile range of 1.34 ? 4.96 ?mol/L.
There was no difference between preterm and term tHcy (median 2.76, IQR 1.25 ? 4.8 ?mol/L vs
median 2.54, IQR 1.55 ? 7.85 ?mol/L, p = 0.07). There was no statistically significant difference in
tHcy in 31 preterm infants with IVH compared to infants without IVH (median 1.96, IQR 1.09 ?
4.35 ?mol/L vs median 2.96, IQR 1.51 ? 4.84 ?mol/L, p = 0.43). There was also no statistically
significant difference in tHcy in 7 infants with periventricular leukomalacia (PVL) compared to
infants without PVL (median 1.55, IQR 0.25 ? 3.45 ?mol/L vs median 2.85, IQR 1.34 ? 4.82 ?mol/
L, p = 0.07). Male infants had lower tHcy compared to female; prenatal steroids were associated
with a higher tHcy.
Conclusion: In our population of preterm infants, there is no association between IVH and tHcy.
Male gender, prenatal steroids and preeclampsia were associated with differences in tHcy levels.
Author's Homepage:
http://people.tcd.ie/amolloyhttp://people.tcd.ie/jscott
Description:
PUBLISHEDPubMed ID: 10907468
Author: SCOTT, JOHN MARTIN; MOLLOY, ANNE MARIE
Type of material:
Journal ArticleCollections:
Series/Report no:
Haematologica84 Suppl
EHA-4
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