Browsing Clinical Medicine by Author "SAUNDERS, SEAN"
Now showing items 1-11 of 11
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Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.
IRVINE, ALAN; SAUNDERS, SEAN; FALLON, PADRAIC (2012)Background Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH. Because higher pH activates SC protease activity, we hypothesized ... -
The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells.
FALLON, PADRAIC; HAMS, EMILY; SAUNDERS, SEAN (2011)Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors HIF-1? and NF-?B via inhibition of oxygen sensing hydroxylase enzymes. Previous studies have ... -
IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
SAUNDERS, SEAN; FALLON, PADRAIC; DONNELLY, SEAMAS (2014)Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models ... -
Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
FALLON, PADRAIC; NEL, HENDRIK; HAMS, EMILY; SAUNDERS, SEAN (2011)Parasitic-infection studies on rhesus macaque monkeys have shown juvenile animals to be more susceptible to infection than adults, but the immunological mechanism for this is not known. In this study, we investigated the ... -
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
FALLON, PADRAIC; SAUNDERS, SEAN (2010)Background and Aims: HIF prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved. Methods: The effect ... -
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
FALLON, PADRAIC; SAUNDERS, SEAN; AMU, SYLVIE; ATZBERGER, ANN (2010)BACKGROUND: Parasitic helminth infections of humans have been shown to suppress the immune response to allergens. Experimentally, infection of mice with the helminth Schistosoma mansoni prevents allergic airway inflammation ... -
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
FALLON, PADRAIC; SAUNDERS, SEAN (2013)Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce ... -
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
FALLON, PADRAIC; AMU, SYLVIE; SAUNDERS, SEAN; NEL, HENDRIK (2011)The incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4+ T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by ... -
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
IRVINE, ALAN; FALLON, PADRAIC; SAUNDERS, SEAN; MCMANUS, ROSS (2015)Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early life, predisposing to asthma development in a phenomenon known as the atopic march. Although genetic and environmental factors are known to ... -
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects
SAUNDERS, SEAN; FALLON, PADRAIC; IRVINE, ALAN (2013)BACKGROUND: Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier ...