Browsing Clinical Medicine by Author "Kelleher, Dermot"
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Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.
Long, Aideen; Kelleher, Dermot; Byrne, Anne-Marie; Foran, Eilis; Sharma, Ruchika; Davies, Antony; Mahon, Ciara; O'Sullivan, Jacintha; O'Donoghue, Diarmuid (2010)Deoxycholic acid (DCA) is a secondary bile acid that modulates signalling pathways in epithelial cells. DCA has been implicated in pathogenesis of colon carcinoma, particularly by activation of the protein kinase C (PKC) ... -
Coagulopathy After Cardiac Surgery May Be Influenced by a Functional Plasminogen Activator Inhibitor Polymorphism
Mc Manus, Ross; Kelleher, Dermot; Ryan, Thomas (2007)BACKGROUND: Cytokine-mediated inflammation and coagulopathy may occur after cardiac surgery. In this study we investigated the temporal pattern of plasminogen activator inhibitor-1 (PAI-1) gene expression after cardiac ... -
Deoxycholic acid impairs glycosylation and fucosylation processes in esophageal epithelial cells.
Kelleher, Dermot; Long, Aideen; Byrne, Anne-Marie; Sharma, Ruchika; Duggan, Gina (2012)It is generally accepted that esophageal adenocarcinoma arises from a Barrett's metaplastic lesion. Altered glycoprotein expression has been demonstrated in tissue from patients with Barrett's esophagus and esophageal ... -
Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study
Feighery, Conleth; Trimble, Valerie; Kennedy, Nicholas; Mc Manus, Ross; Kelleher, Dermot; O'Morain, Colm (2010)BACKGROUND: Recent whole genome analysis and follow-up studies have identified many new risk variants for coeliac disease (CD, gluten intolerance). The majority of newly associated regions encode candidate genes with a ... -
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
Mc Manus, Ross; Feighery, Conleth; Kelleher, Dermot (2007)We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 ? 10?7, empirical genome-wide significance ... -
Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion.
Long, Aideen; Petrovic, Danijela; Stamataki, Zania; Dempsey, Eugene; Golden-Mason, Lucy; Freeley, Michael; Doherty, Derek; Prichard, David; Keogh, Catherine; Conroy, Jennifer; Mitchell, Siobhan; Volkov, Yuri; McKeating, Jane A.; O'Farrelly, Cliona; Kelleher, Dermot (2011)T cell activation and the resultant production of interleukin (IL-2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses sev- eral mechanisms to evade both the ... -
Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals
Mc Manus, Ross; Kelleher, Dermot; Windle, Henry (2005)BACKGROUND: In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the ... -
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
Volkov, Yuri; Kelleher, Dermot; Long, Aideen; Fallon, Padraic; Verma, Navin K.; Dempsey, Eugene; Davies, Anthony; Barry, Sean P. (2012)The immunesuppressive cytokine TGF-β plays crucial regulatory roles in the induction and maintenance of immunologic tolerance and prevention of immunopathologies. However, it remains unclear how circulating T-cells can ... -
Multiple common variants for celiac disease influencing immune gene expression
Mc Manus, Ross; Kelleher, Dermot (2010)We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known ... -
NF-κB regulation: The nuclear response
Mc Manus, Ross; Gray, Steven; Kelleher, Dermot (2009)Nuclear factor ?B (NF-?B) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-?B is involved in a wide range of biological ... -
Phosphorylation of Rab5a protein by protein kinase Cϵ Is crucial for T-cell migration
Long, Aideen; Ong, Seow Theng; Freeley, Michael; Skubis-Zegladło, Joanna; Hussain Urf Turabe Fazil, Mobashar; Kelleher, Dermot; Fresser, Friedrich; Baier, Gottfried; Verma, Navin K. (2014)Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ... -
Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators.
Ryan, Thomas; Doherty, Derek; Kelleher, Dermot; Mc Manus, Ross (2011)INTRODUCTION: Lymphocyte homeostasis is dependent on the ?c cytokines. We hypothesised that sepsis in humans is associated with differential gene expression of the ?c cytokines and their associated apoptosis mediators. ... -
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
SMITH, SINEAD; Ryan, Anthony; Lynch, Mark; Amu, Sylvie; Nel, Hendrik J.; McCoy, Claire E.; Dowling, Jennifer K.; Draper, Eve; O'Reilly, Vincent; McCarthy, Ciara; O'Brien, Julie; Ní Eidhin, Déirdre; O'Connell, Mary J.; Keogh, Brian; Morton, Charles O.; Rogers, Thomas R.; Fallon, Padraic G.; O'Neill, Luke; Kelleher, Dermot; Loscher, Christine E. (2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth
Reynolds, John; Long, Aideen; Duggan, Shane P.; Garry, Catherine; Behan, Fiona; Phipps, Sinead; Kudo, Hiromi; Kirca, Murat; Zaheer, Abdul; McGarrigle, Sarah; Goldin, Robert; Kalloger, Steve E.; Schaeffer, David F.; Strid, Jessica; Kelleher, Dermot (2018)This study de fi nes immune-associated factors supportive of esophageal adenocarcinoma cell growth through small interfering RNA screening and pathologic and functional studies. Fostamatinib R788, targeting Janus ... -
STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL
Long, Aideen; Verma, Navin K.; Davies, Anthony M.; Kelleher, Dermot; Volkov, Yuri (2010)Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas resulting from clonal expansion and localization of malignant T-lymphocytes to the skin. CTCL cells have defective ...