Browsing Clinical Medicine by Author "Keane, Joseph"
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Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey
Keane, Joseph (2008)Tuberculosis control depends on successful case finding and treatment of individuals infected with Mycobacterium tuberculosis. Passive case finding is widely practised: the present study aims to ascertain the consensus and ... -
Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection.
O'Sullivan, Mary; Keane, Joseph; O'Leary, Seonadh (2008)Human macrophages infected with Mycobacterium tuberculosis may undergo apoptosis. Macrophage apoptosis contributes to the innate immune response against M. tuberculosis by containing and limiting the growth of mycobacteria ... -
Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee; O'Sullivan, Mary; O'Neill, Luke (2020)Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis ... -
Editorial: Tregs and BCG - Dangerous liaisons in TB
Keane, Joseph (2010)A discussion on paper by Ho et al. providing evidence to support the hypothesis that Treg cells induced by environmental mycobacteria do indeed constrain immunity induced by BCG. -
The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: A NTM-NET collaborative study.
Keane, Joseph (2013)A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide. To provide a snapshot of NTM species distribution, global partners in the NTM-Network ... -
The immunoregulatory role of CD4 +FoxP3 +CD25 - regulatory T cells in lungs of mice infected with Bordetella pertussis
Keane, Joseph; Finlay, Conor (2012)The identification of regulatory T (Treg) cells was originally based on CD25 expression; however, CD25 is also expressed by activated effector T cells. FoxP3 is a more definitive marker of Treg cells, and CD4 +FoxP3 +CD25 ... -
Inhibiting Histone Deacetylases in Human Macrophages Promotes Glycolysis, IL-1β, and T Helper Cell Responses to Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee (2020)Tuberculosis (TB) is the leading infectious killer in the world. Mycobacterium tuberculosis (Mtb), the bacteria that causes the disease, is phagocytosed by alveolar macrophages (AM) and infiltrating monocyte-derived ... -
Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease
Keane, Joseph (BMC, 2007)Background: Bovine tuberculosis is an enduring disease of cattle that has significant repercussions for human health. The advent of high-throughput functional genomics technologies has facilitated large-scale analyses of ... -
Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV-Infected Individuals in a Low TB Burden Country.
Keane, Joseph; Rogers, Thomas; Bergin, Colm; Clarke, Susan; Ni Cheallaigh, Cliona (2013)Background Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate ... -
Left atrial invasion by pulmonary adenocarcinoma
Keane, Joseph (2007)A 72-year-old female presented with haemoptysis. CT thorax demonstrated a right lower lobe mass infiltrating the left atrium (Fig. 1 ). Bronchoscopy and biopsy confirmed endobronchial adenocarcinoma. Left atrial invasion ... -
Modulating Iron for Metabolic Support of TB Host Defense
Phelan, James; Keane, Joseph; Basdeo, Sharee (2018)Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments are inadequate and there is an ... -
Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis.
Keane, Joseph (2012)Background: Depletion of T cells following infection by Mycobacterium tuberculosis (Mtb) impairs disease resolution, and interferes with clinical test performance that relies on cell-mediated immunity. A number of mechanisms ... -
Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children
Keane, Joseph (Oxford University Press, 2016)Background: Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]). ... -
A pulmonary mass with invasion into the heart
Keane, Joseph (2008)We describe the case of a 58 year old woman who presented with bronchial atypical carcinoid found at surgery to invade the left atrium along the pulmonary veins. A right pneumonectomy and removal of a portion of the ... -
Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.
Palsson Mcdermott, Eva; Keane, Joseph; O'Neill, Luke; Sheedy, Frederick; Johnston, Daniel; Gleeson, Laura (2015)TLR4-activated macrophages switch their metabolism from oxidative phosphorylation to glycolysis to rapidly provide for the high energy and biosynthetic demands of infection or injury response. Palsson-McDermott identify ... -
Response: Disseminated tuberculosis.
Keane, Joseph (Oxford University Press, 2017)Lymphopaenia is described among patients with tuberculosis.The lymphocyte count for the patient in our publication prior to treatment was 0.8 (1–2 1016ml). At the time of writing, he is still receiving his anti-tuberculous ... -
Severity of Elastase-Induced Emphysema Is Decreased in Tumor Necrosis Factor-α and Interleukin-1β Receptor-Deficient Mice
Keane, Joseph (2002)A single intratracheal dose of porcine pancreatic elastase, which is cleared from the lung by 24 hours, was administered to wild-type, IL-1β type 1 receptor-deficient, double TNF-α (type 1 and type 2) receptor-deficient, ... -
T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis
Keane, Joseph (Elsevier, 2007)Autophagy is a recently recognized immune effect or mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune ... -
TB osteomyelitis
Keane, Joseph (Oxford University Press, 2016)Osteoarticular TB is very rare and as such, physicians are less experienced in diagnosing osteoarticular TB. This is compounded by the fact that the diagnosis of osteoarticular TB is difficult to achieve. Therefore, awareness ... -
Understanding and exploiting the effect of tuberculosis antimicrobials on host mitochondrial function and bioenergetics
Phelan, James; Keane, Joseph (2020)Almost 140 years after its discovery, tuberculosis remains the leading infectious cause of death globally. For half a century, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and ...