Browsing Clinical Medicine by Title
Now showing items 732-751 of 947
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Quantum dots in nanomedicine: Recent trends, advances and unresolved issues
(2015)The review addresses the current state of progress in the use of ultra-small nanoparticles from the category of quantum dots (QDs), which presently embraces a widening range of nanomaterials of different nature, including ... -
r2VIM: A new variable selection method for random forests in genome-wide association studies
(2016)Background Machine learning methods and in particular random forests (RFs) are a promising alternative to standard single SNP analyses in genome-wide association studies (GWAS). RFs provide variable importance measures ... -
RACK1 to the future – a historical perspective.
(2013)This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1 ’ s role in the immune system, the heart and the brain were discussed and ... -
RAD51 135G>C modifies breast cancer risk among BRCA2 mutation carriers: Results from a combined analysis of 19 studies
(The American Society of Human Genetics, 2007)Though much progress has been made in understanding the role of two major high-risk breast cancer (BC) susceptibility genes, BRCA1 and BRCA2, it remains unclear what causes the observed variation in risk between mutation ... -
Radioiodine Dosimetry for Benign and Malignant Thyroid Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Thyroid diseases are a common clinical disorder with 5-10% diagnosed as thyroid cancer. The published guidelines that provide clinical guidance for the diagnosis, treatment and management of thyroid diseases, based on a ... -
RanGTPase: A Candidate for Myc-Mediated Cancer Progression
(2013)BACKGROUND: Ras-related nuclear protein (Ran) is required for cancer cell survival in vitro and human cancer progression, but the molecular mechanisms are largely unknown. METHODS: We investigated the effect of the ... -
The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation
(American Society for Nutrition, 2006)Background: Evidence is conflicting as to whether the bioavailability of food folates is influenced by the extent of their conjugation. Objective: The objective was to compare the bioavailability of 3 representative ... -
Real-world outcomes with recombinant factor IX Fc fusion protein in people with haemophilia B in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemophilia B is a rare X-linked bleeding disorder resulting from a deficiency of clotting factor IX (FIX), with severe haemophilia B defined as FIX levels < 0.01 IU/mL. Severe haemophilia is characterised by haemarthrosis, ... -
Receptor tyrosine kinases and their activation in melanoma.
(2011)Receptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression ... -
Reconsidering the causality of TIA1 mutations in ALS
(2018)T-cell-restricted intracellular antigen-1 (TIA1) has been recently reported as a novel amyotrophic lateral sclerosis (ALS) related gene, and has already been adopted in a resource frequently used in ... -
Recurrence of venous thromboembolism in patients with gynaecological cancer incidence, risk factors and impact on survival
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background: Gynaecological malignancy and surgery are independently associated with the highest risks of VTE. However, factors influencing the rate of recurrent VTE in patients with gynaecological malignancy are unknown. ... -
Referral bias in ALS epidemiological studies
(2018)Background: Despite concerns about the representativeness of patients from ALS tertiary centers as compared to the ALS general population, the extent of referral bias in clinical studies remains largely unknown. Using data ... -
Regulating the Regulator: Phosphorylation of PKC θ in T Cells.
(2012)Protein kinase C θ (PKC θ) is a serine/threonine kinase that is now firmly established as a central component in T cell activation, proliferation, differentiation, and apoptosis (Hayashi and Altman, 2007). Since it was ... -
Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
(2013)Suppressor of cytokine signaling (SOCS) proteins are key regulators of CD4+ T cell differentiation, and in particular, we have recently shown that SOCS2 inhibits the development of Th2 cells and allergic immune responses. ... -
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
(2013)Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor κB ... -
Regulation of IL-1?-induced NF-?B by hydroxylases links key hypoxic and inflammatory signaling pathways.
(2013)Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor κB ... -
Regulators of inflammation and innate immunity identified in oesophageal cancer cell viability through implementation of a druggable genome siRNA library screen
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Inflammation initiated by gastroesophageal reflux disease (GORD) can lead to development of oesophageal adenocarcinoma (OAC), through a premalignant lesion, Barrett's oesophagus (BO). OAC has a 5-year survival of patients ... -
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
(2010)BACKGROUND: Parasitic helminth infections of humans have been shown to suppress the immune response to allergens. Experimentally, infection of mice with the helminth Schistosoma mansoni prevents allergic airway inflammation ... -
The relationship between syncope, depression and anti-depressant use in older adults
(2014)The authors aim to examine the rates of depression in older patients reporting syncope and the effect of anti–depressants (ADs) on the rates of syncope. This study demonstrates an increased risk of syncope in patients with ... -
Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
(BioMed Central, 2008)Low serum 25 hydroxyvitamin D3 (vitamin D3) is known to perturb cellular function in many tissues, including the endocrine pancreas, which are involved in obesity and type II diabetes mellitus (TIIDM). Vitamin D3 insufficiency ...
