Browsing Clinical Medicine by Title
Now showing items 506-525 of 947
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L-Plastin Expression in HCT 116 Colorectal Cells increases migration and ROS in an NADPH Oxidase-dependent manner
(2022)Objective: L-plastin is an action-bundling protein normally expressed in cells of haemopoietic origin but is also associated with malignant transformation. Aberrant expression of L-plastin expression correlates with tumour ... -
Laser speckle correlation as a non-contact ocular microtremor measurement technique
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Ocular microtremor (OMT) is high frequency, low amplitude fixational eye movement present in all healthy people. It occurs even while the eye appears to be at rest. Benefits of measuring OMT have been proven in a number ... -
Left atrial invasion by pulmonary adenocarcinoma
(2007)A 72-year-old female presented with haemoptysis. CT thorax demonstrated a right lower lobe mass infiltrating the left atrium (Fig. 1 ). Bronchoscopy and biopsy confirmed endobronchial adenocarcinoma. Left atrial invasion ... -
Lessons of ALS imaging: Pitfalls and future directions - A critical review
(2014)Background: While neuroimaging in ALS has gained unprecedented momentum in recent years, little progress has been made in the development of viable diagnostic, prognostic and monitoring markers. Objectives: To identify ... -
Lethal, neonatal icthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome
(Oxford University Press, 2005)Netherton syndrome is an autosomal recessive multisystemic disorder characterized by congenital ichthyosiform erythroderma, hair shaft defects and atopy, caused by mutations within the human SPINK5 gene. To investigate the ... -
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
(2012)The immunesuppressive cytokine TGF-β plays crucial regulatory roles in the induction and maintenance of immunologic tolerance and prevention of immunopathologies. However, it remains unclear how circulating T-cells can ... -
Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.
(2011)BACKGROUND: Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA). ... -
Leveraging a national patient registry to explore relapse in ANCA associated vasculitis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)BACKGROUND ANCA associated vasculitis (AAV) is an archetypal rare autoimmune disease, resulting in immune-mediated organ damage. It has a relapsing-remitting course, resulting in cumulative morbidity and mortality. Toxic ... -
The life expectancy of Stephen Hawking, according to the ENCALS model
(2018)Stephen W Hawking, one of the most famous physicists, died on March 14, 2018, at the age of 76 years. Although he was best known for his remarkable work on black holes and quantum gravity, he was also a famous patient with ... -
Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
(2015)B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. ... -
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.
(2013)The plasma glycoprotein von Willebrand factor (VWF) exhibits fivefold antigen level variation across the normal human population determined by both genetic and environmental factors. Low levels of VWF are associated with ... -
Long non coding RNAs (lncRNAs) are dysregulated in Malignant Pleural Mesothelioma (MPM).
(2013)Malignant Pleural Mesothelioma (MPM) is an aggressive cancer that is often diagnosed at an advanced stage and is characterized by a long latency period (20–40 years between initial exposure and diagnosis) and prior exposure ... -
Long-term risk of carotid restenosis in patients randomised to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow up of a randomised trial
(2009)Background In the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), early recurrent carotid stenosis was more common in patients assigned to endovascular treatment than it was in patients assigned to ... -
A Longitudinal Study of the Complex Needs of Motor Neuron Disease Caregivers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Motor Neuron Disease (MND) is the term used to describe a number of terminal incurable neurodegenerative disorders, of which Amyotrophic Lateral Sclerosis (ALS) is the most common type. MND is characterised by the progressive ... -
Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring.
(2007)Compromised cobalamin status during pregnancy may put both mother and child at risk of deficiency during lactation and subsequent development. We investigated whether changes in cobalamin status during pregnancy are ... -
A Longitudinal Study of the Evolution of Neuropsychological Change in Amyotrophic Lateral Sclerosis: The Incidence, Nature and Progression of Language Impairment.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Amyotrophic Lateral Sclerosis is a multi-system disease that also affects cognition and behaviour. Cognitive change in ALS manifests most commonly as executive dysfunction. Although changes in language function ... -
A Longitudinal Study of the Evolution of Neuropsychological Change in Amyotrophic Lateral Sclerosis: The Incidence, Nature and Progression of Language Impairment.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Amyotrophic Lateral Sclerosis is a multi-system disease that also affects cognition and behaviour. Cognitive change in ALS manifests most commonly as executive dysfunction. Although changes in language function ... -
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
(2010)Background and Aims: HIF prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved. Methods: The effect ... -
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.
(2011)Background IgE-mediated peanut allergy is a complex trait with strong heritability, but its genetic basis is currently unknown. Loss-of-function mutations within the filaggrin gene are associated with atopic dermatitis ... -
Low 25-hydroxyvitamin D levels in peopel with a solid tumor cancer diagnosis: the tip of the iceberg?
(2014)PURPOSE: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been linked to both cancer incidence and poor prognosis. The frequency of 25(OH)D tests and clinical factors associated with low levels in cancer patients are ...
