Browsing Clinical Medicine by Title
Now showing items 499-518 of 947
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Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on Nutrition and autoimmune disease Nutrition in Crohn s disease
(Cambridge University Press, 2009)The exact aetiology of Crohn's disease remains unknown. The consensus is that the disease results from a complex interaction between genes, immunity and environmental factors. Diet is attractive, in theory, as an environmental ... -
July 2017 ENCALS statement on edaravone
(2017)Neurologists of the ENCALS centers throughout Europe have discussed the potential of edaravone as anew therapy for amyotrophic lateral sclerosis (ALS,Motor Neuron Disease, MND) at the ENCALS meeting, 18–20 May 2017, in ... -
Kaposi sarcoma in an patient with atopic dermatitis treated with ciclosporin.
(2013)There are four clinical subtypes of Kaposi sarcoma (KS): classic, endemic, epidemic and iatrogenic. The geographical prevalence of the endemic variant matches areas of human herpes virus type 8 (HHV8) seroprevalence. The ... -
Ketamine for depression: Clinical use and media accounts
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)This thesis comprises two research studies, one of which is a clinical trial. Study 1: Pilot randomised controlled trial: Ketamine as an adjunctive therapy for major depression, the Karma-Dep Trial (NCT03256162). The ... -
Key research questions for implementation of artificial intelligence in capsule endoscopy.
(2022)Background: Artificial intelligence (AI) is rapidly infiltrating multiple areas in medicine, with gastrointestinal endoscopy paving the way in both research and clinical applications. Multiple challenges associated with ... -
KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment
(2019)KH-type splicing regulatory protein (KHSRP) is a multifunctional nucleic acid binding protein implicated in key aspects of cancer cell biology: inflammation and cell-fate determination. However, the role KHSRP plays in ... -
Kidney Function Estimated From Cystatin C, But Not Creatinine, Is Related to Objective Tests of Physical Performance in Community-Dwelling Older Adults
(2017)Background: The burden of chronic kidney disease is highest among older adults but the significance of a diminished level of kidney function in this heterogeneous population is poorly understood. We sought to examine ... -
L-Plastin Expression in HCT 116 Colorectal Cells increases migration and ROS in an NADPH Oxidase-dependent manner
(2022)Objective: L-plastin is an action-bundling protein normally expressed in cells of haemopoietic origin but is also associated with malignant transformation. Aberrant expression of L-plastin expression correlates with tumour ... -
Laser speckle correlation as a non-contact ocular microtremor measurement technique
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Ocular microtremor (OMT) is high frequency, low amplitude fixational eye movement present in all healthy people. It occurs even while the eye appears to be at rest. Benefits of measuring OMT have been proven in a number ... -
Left atrial invasion by pulmonary adenocarcinoma
(2007)A 72-year-old female presented with haemoptysis. CT thorax demonstrated a right lower lobe mass infiltrating the left atrium (Fig. 1 ). Bronchoscopy and biopsy confirmed endobronchial adenocarcinoma. Left atrial invasion ... -
Lessons of ALS imaging: Pitfalls and future directions - A critical review
(2014)Background: While neuroimaging in ALS has gained unprecedented momentum in recent years, little progress has been made in the development of viable diagnostic, prognostic and monitoring markers. Objectives: To identify ... -
Lethal, neonatal icthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome
(Oxford University Press, 2005)Netherton syndrome is an autosomal recessive multisystemic disorder characterized by congenital ichthyosiform erythroderma, hair shaft defects and atopy, caused by mutations within the human SPINK5 gene. To investigate the ... -
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
(2012)The immunesuppressive cytokine TGF-β plays crucial regulatory roles in the induction and maintenance of immunologic tolerance and prevention of immunopathologies. However, it remains unclear how circulating T-cells can ... -
Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.
(2011)BACKGROUND: Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA). ... -
Leveraging a national patient registry to explore relapse in ANCA associated vasculitis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)BACKGROUND ANCA associated vasculitis (AAV) is an archetypal rare autoimmune disease, resulting in immune-mediated organ damage. It has a relapsing-remitting course, resulting in cumulative morbidity and mortality. Toxic ... -
The life expectancy of Stephen Hawking, according to the ENCALS model
(2018)Stephen W Hawking, one of the most famous physicists, died on March 14, 2018, at the age of 76 years. Although he was best known for his remarkable work on black holes and quantum gravity, he was also a famous patient with ... -
Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
(2015)B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. ... -
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.
(2013)The plasma glycoprotein von Willebrand factor (VWF) exhibits fivefold antigen level variation across the normal human population determined by both genetic and environmental factors. Low levels of VWF are associated with ... -
Long non coding RNAs (lncRNAs) are dysregulated in Malignant Pleural Mesothelioma (MPM).
(2013)Malignant Pleural Mesothelioma (MPM) is an aggressive cancer that is often diagnosed at an advanced stage and is characterized by a long latency period (20–40 years between initial exposure and diagnosis) and prior exposure ... -
Long-term risk of carotid restenosis in patients randomised to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow up of a randomised trial
(2009)Background In the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), early recurrent carotid stenosis was more common in patients assigned to endovascular treatment than it was in patients assigned to ...