Browsing Clinical Medicine by Title
Now showing items 890-909 of 949
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ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients
(2019)Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease that is currently the third leading cause of death worldwide. Recent reports have indicated that dysfunctional iron handling in the lungs of COPD ... -
Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by ?? T Cells.
(2013)Expression of the orphan receptor Toll IL-1R8/single Ig IL-1–related receptor has been reported to be reduced in the peripheral blood of psoriatic arthritis patients. However whether TIR8/SIGIRR activity plays a specific ... -
Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration.
(2020)Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. ... -
Tools and techniques for improving the assessment of exposure to food chemicals
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Exposure assessments are an integral part of risk assessment and are essential for protecting consumer health and factilitating international trade. The aim of this thesis was to explore the potential usefulness of a number ... -
TORCing up the importance of calcium signaling.
(2011-08) -
Total correlation explanation of toxic metal concentrations and physiological biomarkers amongst NHANES participants
(2021)Introduction Unravelling the health effects of multiple pollutants presents scientific and computational challenges. CorEx is an unsupervised learning algorithm that can efficiently discover multiple latent factors in ... -
Towards a nanospecific approach for risk assessment.
(2016)In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the ... -
Towards a unified classification of the ectodermal dysplasias: Opportunities outweigh challenges.
(2009)The ectodermal dysplasias include a complex and highly diverse group of heritable disorders that share in common developmental abnormalities of ectodermal derivatives. The broader definition of ectodermal dysplasias (as ... -
Towards Closing the Care Gap in Bone Health in Gynaecological Oncology
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Loss of bone mineral density (BMD) resulting in osteopaenia, or osteoporosis is relatively common in women, particularly postmenopausal women. Women with gynaecological malignancies are at particular risk due to the effect ... -
Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials
(2018)Nanoparticles (NP)-based inhalation systems for drug delivery can be administered in liquid form, by nebulization or using pressurized metered dose inhalers, and in solid form by means of dry powder inhalers. However, NP ... -
Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects.
(2010)Objective Women who have low cobalamin (vitamin B12) levels are at increased risk for having children with neural tube defects (NTDs). The transcobalamin II receptor (TCblR) mediates uptake of cobalamin into cells. ... -
Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.
(2011)Two polymorphic variants in the gene coding for transcobalamin II ( TCN2 ), TCN2 776C- . Gand TCN2 67A- . G, may alter serum holotranscobalamin (holoTC), which in turn may affect cellular uptake of cobalamin ... -
Transcriptional regulator PRDM12 is essential for human pain perception.
(2015)Pain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which ... -
Transcriptional response to prolonged acid exposure and genetic divergence in Helicobacter pylor
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Helicobacter pylori infection is strongly associated with gastritis, peptic ulcer and gastric adenocarcinoma. Molecular mechanisms involved in H. pylori adaptation and clinical consequences of infection are unclear. This ... -
Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFN? Regulation.
(2015)Genetic studies have to date identified 43 genome wide significant coeliac disease susceptibility (CD) loci comprising over 70 candidate genes. However, how altered regulation of such disease associated genes contributes ... -
Translating molecular approaches for the detection and evaluation of minimal residual disease kinetics in childhood acute lymphoblastic leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Childhood acute lymphoblastic leukaemia (ALL) is the leading cause of cancer-linked mortality identified in children. Approximately 80% of patients are successfully treated. However, 20-25% of patients will still go on to ... -
Treatment of Helicobacter pylori Infection 2011
(2011)This article reviews the literature published pertaining to Helicobacter pylori eradication over the last year. The general perception among clinicians and academics engaged in research on H. pylori has been that eradication ... -
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF?B and Autophagy Dependent Bacillary Killing
(2016)The emergence of multiple-drug-resistant tuberculosis (MDR-TB) has pushed our available repertoire of anti-TB therapies to the limit of effectiveness. This has increased the urgency to develop novel treatment modalities, ... -
Troponin status predicts 30-day in-hospital mortality
(2020)Aim: To evaluate the prognostic value of high-sensitivity cardiac troponin (hscTnT) levels in unselected emergency medical admissions. Methods: We report on all hscTnT tests in emergency medical admissions, ... -
Tumourigenesis and resistance to Interferon alpha-treatment in Cutaneous T-cell Lymphoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Mycosis fungoides (MF) is a Cutaneous T-Cell lymphoma (CTCL) of unknown aetiology, and the mechanisms of tumourigenesis of this lymphoma are unclear. The diagnosis of MF is extremely challenging due to the fact that, in ...