Browsing Clinical Medicine by Title
Now showing items 712-731 of 949
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Profiles of von Willebrand factor antigen, von Willebrand factor propeptide and ADAMTS13 activity in patients with ischaemic cerebrovascular disease after commencing or changing antiplatelet therapy
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: There are very limited data on the impact of commonly-prescribed antiplatelet regimens on von Willebrand Factor antigen (VWF:Ag), von Willebrand Factor propeptide (VWFpp) and A Disintegrin And Metalloprotease ... -
Profiling Serum and Tissue Biomarkers of Vedolizumab Therapy Response in Inflammatory Bowel Disease.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Vedolizumab (VDZ) is a novel biologic agent proven effective for Inflammatory bowel disease (IBD), however, a significant proportion of patients do not respond to VZD treatment Aims: This thesis evaluates ... -
Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
(2013)Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified ... -
Prognostication in advanced cancer by combining actigraphy-derived rest-activity and sleep parameters with routine clinical data: an exploratory machine learning study
(2023)Survival prediction is integral to oncology and palliative care, yet robust prognostic models remain elusive. We assessed the feasibility of combining actigraphy, sleep diary data, and routine clinical parameters to ... -
Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes
(2020)Carbon‐based nanomaterials (C‐BNM) have recently attracted an increased attention as the materials with potential applications in industry and medicine. Bioresistance and proinflammatory potential of C‐BNM is the main ... -
Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells.
(2016)Amorphous silica nanoparticles (ASNP) can be synthetized via several processes, 2 of which are the thermal route (to yield pyrogenic silica) and the wet route from a solution containing silicate salts (to obtain precipitated, ... -
Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis
(Springer Nature, 2018)The most recent genome-wide association study in amyotrophic lateral sclerosis (ALS) demonstrates a disproportionate contribution from low-frequency variants to genetic susceptibility to disease. We have therefore begun ... -
A promising approach to develop nanostructured lipid carriers from solid lipid nanoparticles: preparation, characterization, cytotoxicity and nucleic acid binding ability
(2020)We aimed to develop nanostructured lipid carriers (NLCs) displaying similar characteristics – particle size, polydispersity index, and zeta potential – with the model solid lipid nanoparticles (SLNs) for better comparability. ... -
Propranolol in the treatment of infantile haemangiomas: Lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce Survey.
(2015)BACKGROUND: Oral propranolol is widely prescribed as first line treatment for infantile haemangiomas (IHs) and anecdotally prescribing practice differs widely between centres. OBJECTIVES: The Propranolol In the ... -
Prospective Study of a Novel Diagnostic Algorithm for Investigating and Managing Gastrointestinal Disease Through The Appropriate Use of Biomarkers and Wireless Based Capsule Endoscopy
This chapter gives a general outline of the thesis for better understanding of issues surrounding research areas and studies that have been performed. Lower Gastrointestinal (GI) Symptoms are common and often warrant further ... -
A Prospective Study of the Clinical Content of Palliative Medicine Interdisciplinary Team Meetings
(2014)Structured interprofessional communication should improve the structure and clarity of the plan of care. The interdisciplinary team meeting (IDTM) is an opportunity for shared information on patients' and family care needs. ... -
A prospective, real-world, multinational study of naloxegol for patients with cancer pain diagnosed with opioid-induced constipation - the NACASY Study
(2022)The Naloxegol Cancer Study (NACASY) was a multinational European study aimed to evaluate the 4-week safety and efficacy of naloxegol in a real-world setting in patients with cancer pain diagnosed with opioid-induced ... -
The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure
(Springer Paris, 2017)Background Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could ... -
Protein Kinase C : a key enzyme in mediating interferon-a signalling and a new player in its activity against Hepatitis C infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)The hepatitis C virus (HCV) is a major cause of chronic liver cirrhosis and hepatocellular carcinoma (Lauer and Walker, 2001). The World Health Organisation estimates that there are 170 million individuals infected globally, ... -
?Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival?.
(2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease
(2013)Post-translational modification of proteins by deamidation or transamidation by tissue transglutaminase (tTG) has been suggested as a possible mechanism for the development of autoimmunity. Sequence analysis of protein ... -
Protein Kinase Cη : regulation of expression and functional role in human T lymphocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Protein kinase Cη (PKCη) is a member of the novel PKC subfamily of serine/threonine kinases that has been shown to play critical roles in cell differentiation, proliferation, secretion and apoptosis in several cell types. ... -
Proteomic and cell based approaches for the study of the intestinal epithelial response to Helicobacter pylori soluble components in an ex vivo model of ulcerogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The aim of the present study was to investigate the effects of secreted components of the gastrointestinal pathogen H. pylori on the duodenal epithelium in humans. The effects of H. pylori are not only mediated by direct ... -
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus
(2015)Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for ...