Browsing Clinical Medicine by Title
Now showing items 52-71 of 949
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Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.
(2012)Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). Progress in study of these ... -
Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program.
(2008)BACKGROUND: Bovine tuberculosis (BTB) caused by Mycobacterium bovis continues to cause substantial losses to global agriculture and has significant repercussions for human health. The advent of high throughput genomics ... -
Antimicrobial susceptibility, resistance determinants and molecular epidemiology of Neisseria gonorrhoeae in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)High-level resistance to and treatment failures with ceftriaxone and azithromycin, the first line agents for treatment of gonorrhoea are reported and antimicrobial-resistant N. gonorrhoeae is now an urgent public health ... -
Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo.
(2005)Systemic small vessel vasculitis is associated with antineutrophil cytoplasm antibodies (ANCAs). While there is mounting in vitro evidence to suggest that ANCAs are capable of enhancing leukocyte-endothelial interactions, ... -
Application of probabilistic modelling to food chemical exposure assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Risk assessment of food chemical intake is at the core of food safety policy within the EU and the assessment of food chemical exposure is an integral part of the risk assessment process. There is an increasing demand to ... -
Aspects of muscle performance, mobility limitations, excercise interventions and cognitive functioning in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)In section A, two studies were conducted to systematically investigate and compare the cross sectional and longitudinal physiological determinants of the age-related loss of lower extremity muscle power in healthy and ... -
Assessing brain and cognitive function in multiple sclerosis cross-sectionally and longitudinally with multimodal methods : insights form high-density electrophysiology, neuropsychological examination and magnetic resonance imaging
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Cognitive impairment (CI) affects up to 65% of multiple sclerosis (MS) patients and can occur in the absence of physical disability (Hoffmann, Tittgemeyer, & von Cramon, 2007). MS is the most common chronic inflammatory ... -
Assessing the Efficacy and Safety of Bimodal Neuromodulation for the Management of Symptomatic Tinnitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Tinnitus is defined as the perception of sound in the absence of an external auditory stimulus. It is a common symptom, affecting 5 30% of the general population, however only 1 3% of patients report the symptom to be ... -
Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)5-year survival for pancreatic cancer is about 10% worldwide. A subset of this cancer, pancreatic ductal adenocarcinoma (PDAC), is estimated to become the second leading cause of cancer-related deaths in the US by 2030. ... -
Assessment of platelet activation and function in symptomatic and asymptomatic carotid stenosis, ischaemic stroke and transient ischaemic attack
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Aims: The purpose of this thesis was to comprehensively assess the levels of platelet activation, platelet function and platelet turnover in patients with moderate or severe asymptomatic or symptomatic carotid artery ... -
Assessment of platelet activation and function in the early and late phases following acute TIA and ischaemic stroke
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Aims: The purpose of this thesis was to comprehensively assess the impact of commencing commonly prescribed antiplatelet regimens on platelet activation, platelet function and platelet turnover after TIA or ischaemic stroke, ... -
The association between Fusobacterium nucleatum Outer Membrane Vesicles and Colonic Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Fusobacterium nucleatum, a gram-negative spindle-shaped anaerobic bacterium, is a component of the human microbiome that primarily inhabits the oral cavity and is associated with many diseases, including sinusitis, ... -
Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis.
(American Medical Association, 2016)Importance: Amyotrophic lateral sclerosis (ALS) is a devastating adult-onset neurodegenerative disorder with a poor prognosis and a median survival of 3 years. However, a significant proportion of patients survive more ... -
Association of clinical phenotype and genetic burden in coeliac disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Coeliac disease (CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to a gluten containing diet in genetically predisposed individuals. The clinical presentation of CD is highly ... -
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort
(2021)Background: There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the release ... -
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort
(2020)BACKGROUND: Mitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly ... -
Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
(2021)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Attenuated CSF-1R signalling drives cerebrovascular pathology
(2021)Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood–brain barrier (BBB) disruption are still not ... -
Autosomal dominant tubulointerstitial kidney disease (ADTKD) in Ireland.
(2019)Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare genetic cause of renal impairment resulting from mutations in the MUC1, UMOD, HNF1B, REN, and SEC61A1 genes. Neither the national or ...